Inclusion Criteria:

- Histologically - Or Cytologically- Confirmed Metastatic Or Locally Advanced Solid
Tumors That Has Failed To Respond To Standard Therapy, Or For Which Adequate Standard
Therapy Dose Not Exist

- ECOG Performance Status 0 or 1

- Adequate Organ Function

Exclusion Criteria:

- Patient Who Has Had Chemotherapy, Radiotherapy, Or Biological Therapy Within 4 Weeks
(6 Weeks For Nitrosoureas Or Mitomycin C) Prior To Registration

- Any CNS Metastasis Which Has Symptom Or Requires Treatment

- Any Primary Central Nervous System Tumor

- Any Symptomatic Ascites Or Plural Effusion Which Requires Treatment

- A History Or Current Evidence Of Any Clinically Significant Disease That Might
Confound The Results Of The Study, Complicate The Interpretation Of The Study
Results, Interfere With The Patient'S Participation, Or Pose An Additional Risk To
The Patient