Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma?
- Identify the relationship between intraoral metal contact allergy and epithelial
carcinogenesis in patients with newly or previously diagnosed intraoral squamous cell
- Compare the prevalence of metal contact allergy in these patients with control data
from other existing study populations.
OUTLINE: This is a multicenter study.
- Participants undergo metal patch testing using 27 metals* commonly used in dental
repairs that are part of the Mayo metal series. Metal patches are applied to the
patient's back for 3 days and the back is read on days 3 and 5. Relevant patient data
obtained from their medical and dental history, physical exam, laboratory values and
treatment are documented.
NOTE: *Healthy volunteers (control) undergo metal patch testing using 8 metals most commonly
positive for contact allergens.
Observational Model: Cohort, Time Perspective: Prospective
Relationship between intraoral metal contact allergy and epithelial carcinogenesis
James A. Yiannias, MD
United States: Federal Government
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