Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma?
18 Years
N/A
Both
Head and Neck Cancer
Trial Information
Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma?
OBJECTIVES:
- Identify the relationship between intraoral metal contact allergy and epithelial
carcinogenesis in patients with newly or previously diagnosed intraoral squamous cell
carcinoma.
- Compare the prevalence of metal contact allergy in these patients with control data
from other existing study populations.
OUTLINE: This is a multicenter study.
- Participants undergo metal patch testing using 27 metals* commonly used in dental
repairs that are part of the Mayo metal series. Metal patches are applied to the
patient's back for 3 days and the back is read on days 3 and 5. Relevant patient data
obtained from their medical and dental history, physical exam, laboratory values and
treatment are documented.
NOTE: *Healthy volunteers (control) undergo metal patch testing using 8 metals most commonly
positive for contact allergens.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria:
- Newly or previously diagnosed oral squamous cell carcinoma
- Recruited from the otorhinolaryngology departments of Mayo Clinic Rochester
and Mayo Clinic Arizona
- Healthy volunteer (control)
- No history of intraoral squamous cell carcinoma
- Employed at Mayo Clinic Rochester or Mayo Clinic Arizona
PATIENT CHARACTERISTICS:
- No immunosuppression
- No other conditions that interfere with patch testing
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
Relationship between intraoral metal contact allergy and epithelial carcinogenesis
Outcome Time Frame:
one year
Safety Issue:
No
Principal Investigator
James A. Yiannias, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Mayo Clinic
Authority:
United States: Federal Government
Study ID:
497-00
NCT ID:
NCT00693550
Start Date:
August 2000
Completion Date:
January 2009
Related Keywords:
- Head and Neck Cancer
- lip and oral cavity squamous cell carcinoma
- oropharyngeal squamous cell carcinoma
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms
Name | Location |
|---|---|
| Mayo Clinic | Rochester, Minnesota 55905 |
