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Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma?


N/A
18 Years
N/A
Not Enrolling
Both
Head and Neck Cancer

Thank you

Trial Information

Oral Metal Contact Allergy: A Cause of Oral Squamous Cell Carcinoma?


OBJECTIVES:

- Identify the relationship between intraoral metal contact allergy and epithelial
carcinogenesis in patients with newly or previously diagnosed intraoral squamous cell
carcinoma.

- Compare the prevalence of metal contact allergy in these patients with control data
from other existing study populations.

OUTLINE: This is a multicenter study.

- Participants undergo metal patch testing using 27 metals* commonly used in dental
repairs that are part of the Mayo metal series. Metal patches are applied to the
patient's back for 3 days and the back is read on days 3 and 5. Relevant patient data
obtained from their medical and dental history, physical exam, laboratory values and
treatment are documented.

NOTE: *Healthy volunteers (control) undergo metal patch testing using 8 metals most commonly
positive for contact allergens.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Newly or previously diagnosed oral squamous cell carcinoma

- Recruited from the otorhinolaryngology departments of Mayo Clinic Rochester
and Mayo Clinic Arizona

- Healthy volunteer (control)

- No history of intraoral squamous cell carcinoma

- Employed at Mayo Clinic Rochester or Mayo Clinic Arizona

PATIENT CHARACTERISTICS:

- No immunosuppression

- No other conditions that interfere with patch testing

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Relationship between intraoral metal contact allergy and epithelial carcinogenesis

Outcome Time Frame:

one year

Safety Issue:

No

Principal Investigator

James A. Yiannias, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Mayo Clinic

Authority:

United States: Federal Government

Study ID:

497-00

NCT ID:

NCT00693550

Start Date:

August 2000

Completion Date:

January 2009

Related Keywords:

  • Head and Neck Cancer
  • lip and oral cavity squamous cell carcinoma
  • oropharyngeal squamous cell carcinoma
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms

Name

Location

Mayo ClinicRochester, Minnesota  55905