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Evaluation of Formin Gene Status and Expression in Myeloproliferative and Myelodysplastic Disorders


N/A
18 Years
N/A
Not Enrolling
Both
Myeloproliferative Disorder, MDS, AML

Thank you

Trial Information

Evaluation of Formin Gene Status and Expression in Myeloproliferative and Myelodysplastic Disorders


Leukocytes and myeloid lineage cells from these specimens will be assayed for expression of
DRF genes using standard molecular biological approaches to measure mRNA levels. Extracted
DNA will be analyzed for mutations that affect expressions or function using direct
sequencing techniques.

Alternatively, expression of DRF gene products (mDia proteins) will be assessed using
specific antibodies and flow cytometry. Molecular findings resulting from these assays will
be correlated with clinical information recorded in specimen logbook.


Inclusion Criteria:



- 18 and over

- Male

- Female

- Diagnosed with MDS, MPD and AML

Exclusion Criteria:

- Under the age of 18

- Received bone marrow transplant

Control Group Criteria:

inclusion:

- healthy men and women

- ≥ 55 years of age

exclusion:

- history of hematological condition

- history of cancer

Type of Study:

Observational

Study Design:

Time Perspective: Prospective

Outcome Measure:

to determine if defective DRF1 expression or mDia1 function may contribute to myeloid malignancies and point to mDia1 as an attractive therapeutic target in MDS and MPS

Outcome Time Frame:

within a year

Safety Issue:

No

Principal Investigator

Arthur S Alberts, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Van Andel Research Institute

Authority:

United States: Institutional Review Board

Study ID:

2008-054 Protocol # 080311 AA

NCT ID:

NCT00687414

Start Date:

April 2008

Completion Date:

January 2010

Related Keywords:

  • Myeloproliferative Disorder
  • MDS
  • AML
  • gene expression
  • gene sequencing
  • gene encoding
  • MPD
  • MDS
  • AML
  • mDia
  • Myeloproliferative Disorders

Name

Location
Van Andel Research Institute Grand Rapids, Michigan  49503
St Mary's Health Care Grand Rapids, Michigan  49503