Significance of the High-risk Hpv Viral Load
N/A
18 Years
N/A
18 Years
N/A
Open (Enrolling)
Female
HPV Infections
Female
HPV Infections
Trial Information
Significance of the High-risk Hpv Viral Load
We will particularly evaluate if the HR-HPV viral load:
- Is correlated to the transcription of the genes of the oncoproteins E6 and E7
- Is predictive of the integration of the virus in infected cells
- Is predictive of the presence of HPV in patients' blood
- Influences the local and systemic immunologic response
Inclusion Criteria:
- The women consulting for the therapeutic care (by hysterectomy or conization) of a
LIEHG or a cervical cancer (carcinoma epidermoid or adenocarcinoma) confirmed by the
anatomopathologique analysis of a preoperative cervical biopsy.
- The women having a normal cervix consulting for the surgical care by hysterectomy of
a good-hearted pathology of the womb. The normality of the cervix will be confirmed
by the anatomopathologique analysis of the detail of hysterectomy
- The patients participating in this study will have to be of more than 18 years old.
All the subjects will be profitable of a regime of Social Security.
Exclusion Criteria:
- The patients having a LIEBG
- The patients incapable to receive the information enlightened on the progress and the
objectives of the study
- The patients not having signed enlightened assent
Type of Study:
Interventional
Study Design:
Intervention Model: Parallel Assignment, Masking: Open Label
Outcome Measure:
Estimate the meaning of a viral load raised in HPV oncogenic
Outcome Time Frame:
36 months
Safety Issue:
Yes
Principal Investigator
Xavier CARCOPINO, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Assistance Publique des Hopitaux de Marseille
Authority:
France: Ministry of Health
Study ID:
2007-A01335-48
NCT ID:
NCT00682812
Start Date:
June 2008
Completion Date:
December 2011
Related Keywords:
- HPV Infections
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