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A Pilot Study to Investigate Germ-Line MEN1 and SDHD Gene Mutation in Familial Cases of Carcinoid Cancer


N/A
12 Years
N/A
Open (Enrolling)
Both
Carcinoid Neuroendocrine Cancer

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Trial Information

A Pilot Study to Investigate Germ-Line MEN1 and SDHD Gene Mutation in Familial Cases of Carcinoid Cancer


This proposed pilot study will conduct detailed interviews into the medical, environmental,
and family histories and to collect blood specimen to obtain DNA. The Blood specimen and
DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) to rule out
Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit
D (SDHD), gene inactivation thought to be associated with different types of carcinoid
cancer.


Inclusion Criteria:



1. Over the age of 18 years

2. More than one ,member of a family with a history of biopsy confirmed carcinoid tumor

3. English speaking

4. Mentally and emotionally capable of answering questions

5. Willing and available for study participation

6. At least one other family member with carcinoid tumor

Exclusion Criteria:

1. If you are under the age of 18 years,

2. If you are unable to understand or unable to provide informed consent,

3. If you have a psychological condition (i.e. depression, anxiety disorder, substance
abuse, etc.) which might cause you significant problems in dealing with test results.

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Mutations in MEN1 and SDHD genes

Outcome Time Frame:

1 year

Safety Issue:

No

Principal Investigator

Nancy Gardner, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Rutgers University

Authority:

United States: Institutional Review Board

Study ID:

08-451

NCT ID:

NCT00672269

Start Date:

April 2008

Completion Date:

June 2010

Related Keywords:

  • Carcinoid Neuroendocrine Cancer
  • carcinoid
  • family members
  • familial
  • tumors
  • cancer
  • Carcinoid Tumor

Name

Location

Busch Campus of Rutgers University, Human Genetics InstitutePiscataway, New Jersey  08854-8082