Influence of Insulin Resistance on Cognitive, Emotional and Opioid System Functioning in Women With Polycystic Ovary Syndrome
The pathogenesis of Polycystic Ovary Syndrome (PCOS), a reproductive and metabolic disorder,
is associated with insulin resistance. The effects of insulin resistance on cognition,
mood, opioid system and reproductive function in PCOS affected women are investigated in the
current study. The identification of reversible changes in brain function and reproductive
measures in insulin resistant PCOS patients would likely significantly influence treatment
protocols for these young women.
AIM I. Determine whether identifiable differences can be observed in cognitive and
emotional processing between women with insulin resistant PCOS compared to normal controls
using validated fMRI tasks.
AIM II. Determine whether treatment with oral hypoglycemic agent will alter cognitive
processing as measured with validated fMRI cognitive and emotional tasks.
AIM III. Evaluate the differences in opioid tone in women with insulin resistant PCOS
compared to normal controls.
AIM IV. Evaluate whether an oral hypoglycemic agent is capable of altering opioid tone in
women with insulin resistant PCOS.
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
PCOS affected women will be evaluated prior to and following 4-month metformin treatment utilizing the following measures: OGTT, neuropsychological testing battery, fMRI and PET scanning results.
Yolanda R Smith, MD, MS
University of Michigan, Obstetrics and Gynecology
United States: Institutional Review Board
|University of Michigan, Michigan Clinical Research Unit||Ann Arbor, Michigan 48109|