Inclusion Criteria

- INCLUSION CRITERIA:

1. Healthy men only

2. Age 25-50

3. Screening laboratory evaluations with no clinically significant abnormal results
(minor deviations from normal lab results will be at the discretion of the
principal investigator):

1. fasting comprehensive metabolic panel

2. complete blood count with differential and platelets

3. 75-gram oral glucose tolerance test (OGTT)

- fasting plasma glucose (FPG) < 100 mg/dL

- 2-hr OGTT < 140 mg/dL

4. Insulin-like growth factor-I (IGF-I)

5. thyroid function test (TSH, free T3, free T4)

6. fasting lipid profile

4. BMI < 30

5. Have NOT participated in another clinical trial involving any pharmacologic
agents within the past 60 days

6. Able to complete an inform consent

7. Agree to not participate in other clinical trials within the study period

EXCLUSION CRITERIA:

1. Women

2. FPG 100 mg/dL or 2-hour OGTT 140 mg/dL

3. Abnormal electrocardiogram (EKG) suggesting possible underlying cardiac conditions
that, in the opinion of the investigator(s), may cause participation of the subject
in the study unsafe

4. Positive stool guaiac

5. Evidence of illicit drug use

6. History of smoking any tobacco products within one year prior to screening

7. Alcohol intake > 30 grams (drink more than 2 beers per day OR equivalent amount of
alcohol)

8. History of Human Immunodeficiency Virus (HIV) infection

9. History of active or chronic Hepatitis B and/or C infection

10. History of malignancy

11. History of coronary disease

12. History of seizures or other neurologic diseases

13. History of liver or renal diseases

14. History of gastrointestinal or endocrine disorders

15. History of glucocorticoid use (over one month) or other immunosuppressive agents
(any)

16. unable to undergo a magnetic resonance imaging (MRI) procedure

17. Any medical history that, in the opinion of the investigator(s), will make
participation of the subject in the study unsafe