Weekly Versus Every 3 Week Carboplatin and Paclitaxel in Patients With Ovarian Cancer: a Phase III Randomized Multicenter Study
The standard first-line treatment of ovarian cancer is combination chemotherapy with
carboplatin and paclitaxel, given every 3 weeks. Researchers are looking at new ways of
giving chemotherapy to make it more tolerable and more effective. One way is by giving the
chemotherapy more often in smaller doses. This approach can be associated with fewer or
less troubling side effects. Some chemotherapy drugs such as paclitaxel have been shown to
also be more active when given once a week rather than once every 3 week schedule.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
quality of life
weekly for the first 9 weeks of therapy, then every 3 weeks until the completion of therapy
Sandro Pignata, M.D., Ph.D.
National Cancer Institute, Naples
Italy: Ethics Committee