Inclusion Criteria:

Histology and staging disease:

- Histological proven adenocarcinoma of the colon or rectum

- At least one measurable metastatic lesion according to RECIST criteria

- If only one metastatic lesion, histology is mandatory

Mutation level:

- Tumor tissue (primary or metastasis) typological classified as K-RAS wildtype in
codon 12 and 13 in exon 1 at real-time PCR

General conditions:

- Age >18 and < 75 years

- WHO performance status ≤ 2; life expectancy of more than 3 months

- Adequate haematological function: (Hb ≥ 6.2 μmol/d, ANC ≥ 1.5 x 109/L, platelets ≥
100 x 109/L)

- Adequate renal and hepatic functions: total bilirubin ≤ 1.5 upper normal limit,
creatinine ≤ 1.25 × upper normal limit, ALAT ≤ 3 x upper normal limits, and ≤ 5 x
upper normal limits in case of liver metastases

- Written informed consent prior to randomisation must be obtained and documented
according to the local regulatory requirements

Other:

- Fertile patients must use adequate contraceptives

Exclusion Criteria:

Prior therapy:

- Prior chemotherapy for advanced/metastatic disease

- Adjuvant chemotherapy must have ended > 6 months before inclusion

- Prior treatment with Eloxatin

- Prior treatment with Erbitux or other treatment to EGFR

Prior or current history:

- Current indication for resection with a curative intent

- Evidence of CNS metastasis

- Current infection, unresolved bowel obstruction or subobstruction, uncontrolled
Crohn's disease or ulcerative colitis

- Current history of chronic diarrhea

- Peripheral neuropathy

- Other serious illness or medical conditions (including contraindication to 5 FU e.g.:
angor, myocardial infarction within 6 months, contraindications to monoclonal
antibodies)

- Past or concurrent history of malignant neoplasm other than colorectal adenocarcinoma
within the past five years, except curatively treated non melanoma skin cancer or in
situ carcinoma of the cervix

Concomitant treatments:

- Concomitant (or within 4 weeks before randomisation) administration of any other
experimental drug under investigation

- Concurrent treatment with any other anti-cancer therapy

Other:

- Pregnant or breast feeding women