Inclusion Criteria:

- Signed written informed consent

- Adults over age 18 years of age

- Confirmed advanced solid tumor or lymphoma that may be metastatic or unresectable and
for which standard curative or palliative measures do not exist or are no longer
effective; patients with treated brain or ocular metastases are also eligible

- ECOG performance status of 0-2

- Life expectancy of at least 14 weeks

- Adequate bone marrow reserve

- Adequate liver function as demonstrated by serum bilirubin, alanine aminotransferase
(ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP)

- Adequate renal function (serum creatinine clearance > 60 ml/min)

- Normal coagulation profile (PT/INR and aPTT within institutional normal limits) for
those who give consent to tumor biopsy, within 1 week prior to the procedure.

- Negative pregnancy test for females at Screening, preferably done within 1 week
before Day 1 of dosing (not applicable to patients with bilateral oophorectomy and/or
hysterectomy)

- Willing to abstain from sexual activity or practice physical barrier contraception 28
days before Day 1 of dosing and 6 months after the last dose for the patient

- Signed written informed consent for tumor biopsy for the additional 10 subjects that
will be dosed at the MTD and who have accessible tumors

Exclusion Criteria:

- Unresolved toxicity of higher than Grade 1 severity from previous anti-cancer
treatment or investigational agents

- Receiving or having received investigational agents or systemic anti-cancer agents
within 14 days of Day 1 of dosing or 28 days for those agents with unknown
elimination half-lives or half-lives of greater than 50 hours

- Received extensive radiation therapy including sternum, pelvis, scapulae, vertebrae
or skull, week prior to starting study drug, or who have not recovered from side effects of
such therapy

- Currently taking hormones (i.e., estrogen contraceptives, hormone replacement,
anti-estrogen), anti-platelet agents or anti-coagulants, e.g. coumadin, except for
those who are on prophylactic doses of anti-coagulants for indwelling venous
catheters

- Use of strong inhibitors or inducers of cytochrome P450 3A4 enzymes 2 weeks or 5
half-lives prior to Day 1 of dosing and during the study (refer to Appendix 3)

- Pregnant or breast-feeding

- Major surgery within 4 weeks prior to Day 1 of dosing

- Major surgery to the upper gastrointestinal tract, or inflammatory bowel disease,
malabsorption syndrome or other medical condition that may interfere with oral
absorption

- Signs or symptoms of end organ failure, major chronic illnesses other than cancer, or
any severe concomitant conditions which, in the opinion of the investigator, makes it
undesirable for the subject to participate in the study or which could jeopardize
compliance with the protocol

- History of angina pectoris, coronary artery disease or cerebrovascular accident,
transient ischemic attack or cardiac arrhythmia requiring medical therapy

- Evidence of hepatitis B or C, human immunodeficiency (HIV) infection, coagulation
disorders, or hemolytic conditions, e.g. sickle cell anemia