Trial Information

Follow-up of Kidney Cancer Patients From the Central European Multicenter Case-Control Study

Previously we proposed to conduct a follow-up study of kidney cancer in the high risk region
of Central and Eastern Europe. This study was conducted through the follow-up of a group of
patients with kidney cancer, that were previously enrolled in the study entitled,
Occupation, Genetic Susceptibility Kidney Cancer: Central European Case-Controls Study, PI
Dr. Wong-Ho Chow, OEEB, DCEG, NCI, protocol No 01-C-NO63, a study for which field work and
data analyses of the case control study were completed. We had originally planned to conduct
the follow-up study in seven centers in four countries, including Romania, Poland, Russia,
and the Czech Republic. In each center, cancer-related information was to be extracted from
vital statistics, cancer registry, and/or medical records. For deceased patients,
next-of-kin were to be interviewed using a brief questionnaire.

A pilot study was conducted to determine the feasibility of collecting survival information
including 5-year survival status, date of death, cause of death, and date of last follow-up
if alive from 220 cases across the seven collaborating centers. The feasibility of
extracting additional data including surgical and medical treatment procedures used to treat
primary disease, the recurrence and progression of primary disease was also determined.
However, based on results obtained from the pilot study, we determined that it is feasible
to collect follow-up data from kidney cancer cases from four centers in the Czech Republic
and one center in both Poland and Russia.

Medical records/archives for Romanian cases were located in hospitals that were completely
destroyed during reconstruction therefore, it was impossible to collect any information from
this subset of patients. Exclusion of these records will not affect study power since most
of the cases were from the Czech Republic. The objective of our proposed study remains the
same:( 1) to assess the 5-year survival status of kidney cancer patients in the Central and
Easter European Renal Cell Carcinoma Study; (2) to examine prevalence of recurrent disease
and progression; (3) to investigate additional patient-tumor-and genetic determinant of
5-year survival in cases.