Inclusion Criteria:

- Patients with refractary or relapsed multiple myeloma

- ECOG ≤ 3

- Life expectancy > 3 months

- Neutrophils account ≥ 0.5 X 10^9/L, platelets ≥ 30 X 10^9/L.

- Transaminases <3 times upper normal limit, bilirubin < 2 times upper normal limit

- Age > 18 years

- Time after last chemotherapy or radiotherapy > 1 month or time after transplantation
> 2 months.

- No possible other actual treatment

- Written consent form

Exclusion Criteria:

- Candidate to second transplantation

- No following criteria

- Other neoplasties

- Peripheral neuropathy > Grade 2.

- Previous ileus paralytic

- Hepatic failure

- No controlled infection

- No controlled high calcium levels

- Any organic insufficiency that no permit follow the correct treatment

- Pregnancy, breast feeding or fertility without anticonceptive method

- Any psychological, social and/or familiar event that no permit follow the correct
treatment

- Diabetes mellitus not controled