Regulatory T Cells at Engraftment as Predictors of Acute Graft-Versus-Host Disease Outcomes in Patients Undergoing Allogeneic Stem Cell Transplantation
- To determine the association between regulatory T-lymphocyte (Treg) subsets present at
engraftment and at day 28 with the incidence of acute graft-versus-host-disease (aGVHD)
in patients undergoing allogeneic stem cell transplantation.
- To identify gut-homing and skin-homing Treg subsets and determine their role during
engraftment and at day 28 as a predictor of gut and skin aGVHD, respectively.
OUTLINE: Patients undergo blood sample collection at the time of neutrophil engraftment
prior to stem cell transplant (SCT) and post-SCT on days 7, 14, 21, and 28 days after
allogeneic stem cell transplantation. Blood samples are analyzed for T-cell subsets and for
the percentage of regulatory T-lymphocyte (Treg) or other T-cell subsets expressing specific
homing receptors for the gut or skin via flow cytometry.
Patients' medical records are also reviewed periodically.
Observational Model: Cohort, Time Perspective: Prospective
Percentage of regulatory T-lymphocytes (Tregs) at engraftment
percentage of Treg subsets present in patient's blood before they undergo stem cell transplant
day of stem cell transplant
Brian Engelhardt, MD
Vanderbilt-Ingram Cancer Center
United States: Federal Government
VICC BMT 0653
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|