Inclusion Criteria:

- The diagnosis of HCC was based on the diagnostic criteria for HCC used by the
European Association for the Study of the Liver (EASL)

- Tumor size >7 cm with a portal vein invasion, and the tumor was considered to be
unresectable

- No previous HCC directed treatment

- Eastern Co-operative Group performance status 0-1

- Liver function: Child's A

Exclusion Criteria:

- Avascular tumor

- Evidence of hepatic decompensation including ascites, gastrointestinal bleeding or
hepatic encephalopathy

- underlying serve cardiac or renal diseases

- Known or suspected allergy to the investigational agent or any agent given in
association with this trial

- Diffuse-type HCC

- For patients with main portal vein occlusion, no adequate collateral circulation
around the occluded portal vein