Inclusion Criteria:

- Signed and dated informed consent.

- Histologically confirmed cancer refractory to conventional therapy or refractory
cancer for which there is no known effective or standard therapy.

- Measurable or non-measurable disease.

- Male or female, 18 to 75 years of age, inclusive.

- ECOG Performance Status 0-2

- Life expectancy greater than 24 weeks.

- Able to swallow the oral capsule form of the drug.

- Hematology: Hemoglobin greater than or equal to 8.5; Platelets greater than or equal
to100,000; Neutrophils greater than or equal to 1500

- PT and PTT within normal limits, except for patients receiving oral Vitamin K
antagonist for thromboembolic prophylaxis, in whom an INR less than 2 is allowable.

- Biochemistry: Total bilirubin less than or equal to 1.5 x ULN; AST/ALT less than or
equal to 3.0 x ULN; Serum creatinine less than or equal to 2.0 mg/dl; Serum calcium
less than or equal 11.5 mg/dl; Fasting serum triglycerides less than or equal 2.5 x
ULN

- Endocrine: Thyroid stimulating hormone (TSH)within institutional normal limits
(typically greater than 0.5 mU/L and less than 5.5 mU/L)

- Negative urine pregnancy test for women of child-bearing potential at screening and
on Day 0, and agreement to use two reliable forms of contraception during therapy and
for 1 month following discontinuation of therapy unless abstinence is the chosen
birth control method.

- Able to follow study instructions, accessible for treatment and follow-up, and likely
to complete all study requirements

Exclusion Criteria:

- Major surgery within previous 4 weeks; large field radiation therapy or chemotherapy
,including investigational agents or participation in another clinical study within
previous 3 weeks; mitomycin C or nitrosoureas within 6 weeks. In all instances
patients must have fully recovered from acute toxicities related to prior therapies.

- Systemic retinoid therapy, or large doses of Vitamin A during previous 4 weeks.

- Patients with any prior or current history of thyroid disease, with any history of
pituitary disease, or with any history of prior or current treatment with thyroid
replacement hormone.

- Primary brain tumors, active brain metastasis including progression from last scan or
evidence of cerebral edema, or clinical symptoms of brain metastasis. Patients with
prior history of brain metastasis must have brain imaging performed and be found to
be stable or improving over a minimum interval of 8 weeks.

- Requirement for steroids. Note:Patients taking stable dosages of GnRH analogues or
Megace for at least the previous 3 months will be allowed into the study.

- Current enrollment in an investigational drug or device study or participation in
such a study within 21 days of entry into this study.

- Prior enrollment in the study (Quest 194204-101-00); patients may only enroll once
and be treated only at one dose level.

- Known sensitivity to any of the ingredients in the study medication.

- Known HIV-positive patients.

- Females who are pregnant, nursing, or planning a pregnancy.

- History of gastrointestinal disorders (medical disorders or extensive surgery) which
may interfere with absorption of study medication.

- Clinically significant abnormalities on screening ECG (QTc greater than 480 msec).

- Patient has a condition or is in a situation that, in the investigator's opinion, may
put him/her at significant risk, may confound the study results, or may interfere
significantly with his/her participation in the study