Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma
N/A
N/A
Both
Hepatitis B, Hepatocellular Carcinoma, Chronic Liver Disease
Trial Information
Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma
Hepatitis B virus (HBV)infection is the major risk factor for chronic liver disease and
hepatocellular carcinoma (HCC). Host immunogenetic factors contribute to HBV-associated
liver damage and/or carcinogenesis. Variant cytokine alleles, including tumor necrosis
factor-α(TNF-α)and interleukin-1β(IL-1β), might contribute to interindividual difference in
inflammatory responses and account for heterogeneous disease outcome of infectious disease.
By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of
cytokine gene polymorphisms(and their interaction) on susceptibility and severity of
HBV-related HCC.
Inclusion Criteria:
- HBsAg-positive patients
Exclusion Criteria:
- HBsAg-negative patients
Type of Study:
Interventional
Study Design:
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Outcome Measure:
cytokine polymorphisms increase risk for hepatocellular carcinoma
Outcome Time Frame:
years
Safety Issue:
No
Principal Investigator
Jung-Fa Tsai, M.D., Ph.D.
Investigator Role:
Principal Investigator
Investigator Affiliation:
Professor of Medicine
Authority:
Taiwan: Department of Health
Study ID:
KMUH-IRB-950181
NCT ID:
NCT00629486
Start Date:
January 2007
Completion Date:
May 2008
Related Keywords:
- Hepatitis B
- Hepatocellular Carcinoma
- Chronic Liver Disease
- cytokine gene
- hepatitis B
- hepatocellular carcinoma
- chronic liver disease
- Carcinoma
- Hepatitis
- Hepatitis A
- Hepatitis B
- Liver Diseases
- Carcinoma, Hepatocellular
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