Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma
Hepatitis B virus (HBV)infection is the major risk factor for chronic liver disease and
hepatocellular carcinoma (HCC). Host immunogenetic factors contribute to HBV-associated
liver damage and/or carcinogenesis. Variant cytokine alleles, including tumor necrosis
factor-α(TNF-α)and interleukin-1β(IL-1β), might contribute to interindividual difference in
inflammatory responses and account for heterogeneous disease outcome of infectious disease.
By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of
cytokine gene polymorphisms(and their interaction) on susceptibility and severity of
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
cytokine polymorphisms increase risk for hepatocellular carcinoma
Jung-Fa Tsai, M.D., Ph.D.
Professor of Medicine
Taiwan: Department of Health