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A Pilot Study of PET-CT in the Assessment of Pulmonary Nodules in Children With Malignant Solid Tumors


N/A
N/A
21 Years
Not Enrolling
Both
Pulmonary Nodules

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Trial Information

A Pilot Study of PET-CT in the Assessment of Pulmonary Nodules in Children With Malignant Solid Tumors


In this study, we seek to assess the feasibility of performing PET-CT for the evaluation of
pulmonary nodules in children to obtain preliminary data for sample size determination for a
larger multi-institutional trial. The primary objective of the multi-institutional trial
will be to compare the accuracy of diagnostic CT alone to PET-CT in distinguishing benign
from malignant nodules in children with solid malignancies. We are hopeful that PET-CT will
allow us to better direct the clinical management of these patients and to reduce the number
of invasive procedures performed to confirm the presence of benign disease.


Inclusion Criteria:



- Participant has a known or clinically suspected solid malignancy (excluding brain
tumor)

- Nodule must be discovered at the time of diagnosis of the primary malignancy or after
the completion of therapy

Exclusion Criteria:

- Participant has not been off therapy for at least 3 weeks before undergoing PET-CT

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Cross-Sectional

Outcome Measure:

To assess the feasibility of performing PET-CT for the evaluation of pulmonary nodules in children with solid malignancies and to obtain preliminary data for sample size determination for a larger, multi-institutional prospective study.

Outcome Time Frame:

2 years

Safety Issue:

Yes

Principal Investigator

Mary E McCarville, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

St. Jude Children's Research Hospital

Authority:

United States: Institutional Review Board

Study ID:

PETPUL

NCT ID:

NCT00629460

Start Date:

February 2008

Completion Date:

April 2012

Related Keywords:

  • Pulmonary Nodules
  • Pulmonary Nodules
  • Lung Neoplasms
  • Neoplasms

Name

Location

Mary E. McCarvilleMemphis, Tennessee  38105