Inclusion Criteria:

- Histologically- or cytologically- confirmed Non-Small-Cell Lung Cancer Stage IIIB/IV

- No prior chemotherapy

- Existence of measurable disease. The measurable disease should not have been
irradiated

- Life expectancy of more than 3 months

- Age ≥ 70 years

- Performance status (ECOG):1 or 2

- Adequate bone marrow function (Absolute neutrophil count >1500/mm^3, Platelet
count>100000/mm^3, Hemoglobin>9gr/mm^3)

- Adequate liver (Bilirubin<2 times upper limit of normal and SGOT/SGPT<3 times upper
limit of normal) and renal function (creatinine<1.5mg/dl)

- Informed consent

Exclusion Criteria:

- Psychiatric illness or social situation that would preclude study compliance.

- Other concurrent uncontrolled illness.

- Other invasive malignancy within the past 5 years except nonmelanoma skin cancer

- Currently/recently taken warfarin, phenprocoumon or phenytoin

- Hypersensitivity history to any drug