Effect of Antireflux Therapy on the Expression of Genes Known to be Important in Inflammation, Metaplasia and Neoplasia in Patients With GERD
Aims: To determine the effects of antireflux therapy (pump inhibitor and surgical
fundoplication) on gene expression of:
1. inflammation: IL-8, IFN-g, TNF-a.
2. intestinal metaplasia: CDX-1/2, MUC2 and Sonic hedgehog.
3. Neoplasia: Cox-2, VEGF, and EGFR.
Observational Model: Cohort, Time Perspective: Prospective
before and after treatment
Jeffrey H Peters
University of Rochester
United States: Institutional Review Board
|Strong Memorial Hospital||Rochester, New York 14642|