Inclusion Criteria

Inclusion Criteria

- Patients with radiographically proven recurrent, intracranial malignant glioma will
be eligible for this protocol.

- All patients must sign an informed consent

- Patients must have had external beam radiation; there is no limit to the number of
prior chemotherapies used.

- Patients must be > 18 years old, and with a life expectancy > 8 weeks.

- Patients must have a Karnofsky performance status of > 60.

- At the time of registration: Patients must have recovered from the toxic effects of
prior therapy:

- Patients must have adequate bone marrow function.

- Patients must have shown unequivocal radiographic evidence for tumor progression by
MRI

- Patients having undergone recent resection of recurrent or progressive tumor will be
eligible as long as all of the following conditions apply: They have recovered from
the effects of surgery. Residual disease following resection of recurrent
intracranial malignant glioma is not mandated for eligibility into the study.

- Patients must have failed prior radiation therapy and must have an interval of
greater than or equal to 42 days from the completion of radiation therapy to study
entry.

- Patients with prior therapy that included interstitial brachytherapy, stereotactic
radiosurgery, or Gliadel wafers must have confirmation of true progressive disease
rather than radiation necrosis based upon either PET or MR spectroscopy or surgical
documentation of disease.

- Male and female patients with reproductive potential must use an approved
contraceptive method

Exclusion Criteria

- Patients must not have any significant medical illnesses that in the investigator's
opinion cannot be adequately controlled with appropriate therapy or would compromise
the patient's ability to tolerate this therapy

- Patients with a history of any other cancer (except non-melanoma skin cancer or
carcinoma in-situ of the cervix), unless in complete remission and off of all therapy
for that disease for a minimum of 3 years are ineligible.

- Patients must not have active infection or serious intercurrent medical illness.

- Patients must not be pregnant/breast feeding and must agree to practice adequate
contraception.