Trial Information

Evaluation of Effectiveness of Preoperative Percutaneous Radiofrequency Ablation of Primary and Secondary Lung Tumors

Thermal ablation therapy is an increasingly performed technique in the local tumor
treatment. Among these techniques, image-guided radiofrequency (RF) ablation attained
widespread consideration in the therapy of liver tumors and osteoid osteoma. Promising
results of hepatic RF ablation raised expectations to utilize the advantages of image-guided
ablation therapy for the treatment of pulmonary malignancies. The purpose of the study is to
evaluate the effectiveness of radiofrequency ablation by pathological correlation and to
characterize the tissue response after treatment of primary and secondary pulmonary tumors.
Computed tomography-guided RF ablation is performed in local or general anesthesia, followed
by surgical resection three days later. An analysis of complete RF ablation and a
characterization of tissue response is performed by hematoxylin and eosin staining,
immunostaining, and electron microscopy. Adverse effects and complications are recorded.