Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy
Inclusion Criteria:
- Diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL),
acute undifferentiated or biphenotypic leukemia, myelodysplastic syndrome (MDS),
Hodgkin's lymphoma, (HL) or non-Hodgkin's lymphoma (NHL), and in complete remission
at the time of enrollment
- Are scheduled to undergo conditioning treatment with (1) total body radiation (TBI)
and chemotherapy or (2) chemotherapy alone prior to receiving a myeloablative
allogeneic HSCT
- Between 18 and 70 years of age.
- Are English speaking.
- Have capacity to give consent.
Healthy Control
Inclusion Criteria:
- Have no diagnosis of cancer except basal cell carcinoma
- Between 18 and 70 years of age.
- Are English speaking.
- Have capacity to give consent
Exclusion Criteria:
- Patients with signs and/or symptoms of central nervous system disease as determined
by their physician or by a brain MRI, either at the time of enrollment or during the
study period.
- With disease progression at the time of enrollment or during the study period
- With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia
- With a history of a neurological disorder, neurodegenerative disease, or traumatic
brain injury with loss of consciousness
- With standard contraindications to MRI examinations
Healthy Control Exclusion Criteria:
- Exposure to chemotherapy or radiation therapy for any medical condition
- With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia
- With a history of neurological disorders, neurodegenerative disease, or traumatic
brain injury with loss of consciousness
- With standard contraindications to MRI examinations