Inclusion Criteria:

- Patients diagnosed with large uveal melanomas who elect to undergo enucleation.

- Patients diagnosed with uveal melanomas with tumor thickness > 10 mm or basal
diameter > 16 mm, as measured by ultrasound examination, funduscopic examination, or
transillumination.

Exclusion Criteria:

- Cases that do not meet the above criteria for tumor size will be ineligible to
participate in the study.

- Patients with history of metastatic cancer (other than melanoma).

- Patients not able to provide consent for the study.

- Patients with clinical or radiographic evidence of extraocular extension of the
tumor.

- Patients with a previous history of an adverse reaction to intravitreal injection.

- Patients with a poor view of the fundus due to cataract or vitreous hemorrhage.

- Patients with intravitreal silicone oil or gas tamponade.

- Patients < 18 years of age.

- Women known to be pregnant.