Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging
The purpose of this investigation is to determine cortical mechanisms of adaptation to
surgical or radiation treatment to the tongue. This study will use a non-invasive imaging
technique, Functional Magnetic Resonance Imaging (fMRI), to investigate cortical responses
to partial glossectomy or radiation therapy for treatment of a tongue malignancy. Patients
with Stage I-IV (AJCC) malignancies of the tongue who are treated with surgery and or
radiation therapy will be imaged using fMRI pre-operatively and at approximately six months
Patterns of brain activity from the fMRI studies will be compared with matched healthy
control subjects. The results of this investigation will provide needed information on both
central and peripheral mechanisms of adaptation.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
To utilize fMRI to characterize adaptation to alterations in tongue morphology & function following either surgical therapy, or radiation/chemotherapy to tongue in patients undergoing treatment of malignancies involving the tongue.
Kyung Peck, PhD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
|Memorial Sloan Kettering Cancer Center||New York, New York 10021|