Inclusion Criteria:

Inclusion criteria for the tongue carcinoma patients:

- Primary malignancy of the oral or base of tongue, Stage I-IV of AJCC staging system,
planned for surgical or radiation therapy.

Inclusion criteria for the healthy subjects:

- Healthy adult subjects between the ages of 21-75 years.

Exclusion Criteria:

Exclusion criteria for the tongue carcinoma patients include the following:

- History of significant psychiatric condition (e.g. schizophrenia,
obsessive-compulsive disorder, significant dementia),

- History of the following neurological conditions: CVA, seizure disorders,
demyelinating conditions, systemic neuromuscular disorders, cerebral palsy,
Alzheimer's disease.

- History of previous moderate to severe traumatic brain injury.

- History of significant cardiovascular, respiratory, gastrointestinal or renal disease
(e.g.myocardial infarction within the previous 12 months, significant vaso-occlusive
disease,severe or advanced asthma, COPD, emphysema, gastroesophageal reflux disease,
or renal compromise)

- History of achalasia

- History of other neoplasms involving the brain, head and neck, or gastrointestinal
system.

- History of dysphagia, odynophagia, or aphasia unrelated to present illness.

- History of significant claustrophobic reactions.

- Standard contraindications to MR examinations (e.g. implanted stimulators).

Exclusion criteria for the healthy subjects includes the all of the conditions listed for
the tongue:

- Carcinoma patients and additionally includes history of significant surgery or
previous radiation therapy to the head and neck

- Previous history of dysphagia, odynophagia, aphasia, pregnancy,and standard
contraindications to MR examinations.