High-Dose Proton/Photon RT + Surgery of Sarcomas of the Thoracic, Lumbar Spine/Sacrum
- In this study three types of radiation will be used: standard radiation (called
photon); alternative form of radiation called proton beam therapy; and a localized
radiation applicator plaque that can be applied to the surface of the dura (the fibrous
outer envelope that surrounds the spinal cord and fluid surrounding the spinal cord) at
time of surgical removal of the tumor.
- Radiation treatments (photon and proton) and possibly surgical removal of portions of
the tumor with intraoperative radiation delivery to the surface dura with
intraoperative radiation delivery will be performed over a period of 12 weeks. As part
of the treatment planning process, participants will need two treatment planning CT
scans and 2-3 treatment planning sessions.
- Participants will receive, in total, 39-43 photon/proton treatments.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To define the efficacy of high dose fractionated radiation alone or combined with surgery in this patient population.
Thomas F. DeLaney, MD
Massachusetts General Hospital
United States: Institutional Review Board
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|