Inclusion Criteria:

- Have 1-3 newly diagnosed supratentorial metastatic brain lesions with at least one
being dominant and eligible for surgical resection as visualized on enhanced MRI scan

- Have histological evidence of metastatic carcinoma on intraoperative pathology
(frozen section) or final pathology report

- Have a Karnofsky Performance Status (KPS) >=70

- Have systemic disease which is judged to be stable and has been staged within the
last 6 weeks

- Have a life expectancy of >= 6 month, based upon extent of systemic disease

- Be at least 18 years of age Give informed consent (or have legal representative give
informed consent)

Exclusion Criteria:

- Be receiving or have plans to receive conventional or investigational systemic agents
for the metastatic brain tumor.

- Be receiving or have plans to receive external beam radiation therapy to the brain.

- Have received prior conventional or investigational systemic agents, including the
use of Gliadel Wafers or Temodar, for the treatment of the brain metastasis.

- Be pregnant or breast-feeding.

- Have uncontrolled hypertension, unstable angina pectoris, evidence of uncontrolled
cardiac dysrhythmia.

- Have other serious concurrent infection or other medical illness which would
jeopardize the ability of the patient to safely undergo resection and brachytherapy.

- Have histology of lymphoma or small-cell lung cancer.