Inclusion Criteria:

- Patients with osteosarcoma are the study group

- Patients with malignant diagnoses other than osteosarcoma, neuroblastoma, Ewing's
sarcoma or synovial sarcoma may participate as controls

- Histologically proven osteosarcoma or a history of histologically proven osteosarcoma
are eligible for participation. The patient does not need to be newly diagnosed for
enrollment on this protocol

- Patients with malignant diagnosis other than osteosarcoma, neuroblastoma, Ewing's
sarcoma or synovial sarcoma are eligible to participate if they have a central venous
catheter and routine blood work is being drawn

Exclusion Criteria:

- Patients less then three years of age

- Patients with Ewing's sarcoma, neuroblastoma and synovial sarcoma will be excluded
from this protocol