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Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical Outcome


N/A
N/A
N/A
Open (Enrolling)
Both
Neuroblastoma

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Trial Information

Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical Outcome


To collect tumor, marrow specimens prospectively to study the molecular-genetic makeup of
individual neuroblastic tumor and its metastasis by blood and marrow, and to correlate these
findings with clinical outcome, and to relate the signaling circuitry of neuroblastic tumors
to that of embryonic neuroectodermal cells. .


Inclusion Criteria:



- Neuroblastic tumors diagnosed in accordance with the International Neuroblastoma
Staging System viz., either (a) histologic confirmation (by the MSKCC Department of
Pathology) which may involve immunohistochemical, ultrastructural, or cytogenetic
studies, or (b) elevated urinary catecholamines plus tumor cells/clumps in the bone
marrow.

OR

- Clinically suspected neuroblastic tumors prior to diagnostic surgery.

Exclusion Criteria:

- None

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To study the molecular-genetic makeup and metastasis of neuroblastic tumors.

Outcome Time Frame:

Before surgery and a maximum of 10 times

Safety Issue:

No

Principal Investigator

Nai-Kong Cheung, M.D., Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

00-109

NCT ID:

NCT00588068

Start Date:

September 2000

Completion Date:

September 2013

Related Keywords:

  • Neuroblastoma
  • Adrenal Gland
  • No stage requirement
  • Neuroblastoma

Name

Location

Memorial Sloan-Kettering Cancer CenterNew York, New York  10021