Know Cancer

forgot password

Estrogen, Diet, Genetics and Endometrial Cancer

21 Years
Open (Enrolling)
Cancer, Endometrial Cancer, Ovarian Cancer, Corpus Uteri, Endometrium

Thank you

Trial Information

Estrogen, Diet, Genetics and Endometrial Cancer

We will conduct a population-based case-control study in six counties of New Jersey. Cases
will be women with newly-diagnosed endometrial or ovarian cancer. Controls will be matched
by 5-year age groups and selected by random digit dialing (for those under 65), from Centers
for Medicare and Medicaid Services (CMS) files (for those 65 and over), or from neighborhood
sampling. Controls will not have had a hysterectomy.

There will be 400 cases with endometrioid tumors, 60 with serous tumors or clear cell
tumors, 300 with ovarian cancer, and 400 controls. In addition, there will be a small group
of black women included from MSKCC.

We will interview participants about known and potential risk factors for endometrial and
ovarian cancer and obtain information on diet. We will obtain DNA for genetic analysis from
buccal specimens collected using a mouthwash rinse method. We will use logistic regression
to determine odds ratios for disease with various exposures. For endometrial cancer, we will
examine the association of risk with genotypes in strata defined by body mass index and
dietary fat consumption.

Inclusion Criteria:

- Diagnosed with epithelial endometrial or ovarian cancer within the year before being
contacted (cases)

- Aged 21 and over

- Residents of Essex, Union, Morris, Middlesex, Bergen, or Hudson counties, NJ

- Black women with and without endometrial cancer who are seeing gynecologists at MSKCC

Exclusion Criteria:

- Unable to sign informed consent

- Consent withheld by physician (cases)

- Hysterectomy (controls)

- Do not speak English or Spanish

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

To investigate the role of weight, diet, and individual genetic susceptibility to endometrial cancer

Outcome Time Frame:

3 years

Safety Issue:


Principal Investigator

Sara Olson, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

September 2001

Completion Date:

December 2013

Related Keywords:

  • Cancer
  • Endometrial Cancer
  • Ovarian Cancer
  • Corpus Uteri
  • Endometrium
  • Cancer
  • Endometrial cancer
  • Ovarian cancer
  • Corpus Uteri
  • Endometrium
  • Endometrial Neoplasms
  • Sarcoma, Endometrial Stromal
  • Ovarian Neoplasms
  • Adenoma



Memorial Sloan-Kettering Cancer Center New York, New York  10021