Estrogen, Diet, Genetics and Endometrial Cancer
We will conduct a population-based case-control study in six counties of New Jersey. Cases
will be women with newly-diagnosed endometrial or ovarian cancer. Controls will be matched
by 5-year age groups and selected by random digit dialing (for those under 65), from Centers
for Medicare and Medicaid Services (CMS) files (for those 65 and over), or from neighborhood
sampling. Controls will not have had a hysterectomy.
There will be 400 cases with endometrioid tumors, 60 with serous tumors or clear cell
tumors, 300 with ovarian cancer, and 400 controls. In addition, there will be a small group
of black women included from MSKCC.
We will interview participants about known and potential risk factors for endometrial and
ovarian cancer and obtain information on diet. We will obtain DNA for genetic analysis from
buccal specimens collected using a mouthwash rinse method. We will use logistic regression
to determine odds ratios for disease with various exposures. For endometrial cancer, we will
examine the association of risk with genotypes in strata defined by body mass index and
dietary fat consumption.
Observational Model: Case Control, Time Perspective: Prospective
To investigate the role of weight, diet, and individual genetic susceptibility to endometrial cancer
Sara Olson, PhD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
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