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Studies of Neurological Paraneoplastic Syndromes


N/A
18 Years
N/A
Not Enrolling
Both
Paraneoplastic Neurologic Degenerations (PNDs)

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Trial Information

Studies of Neurological Paraneoplastic Syndromes


Patients usually go to their doctors with neurological complaints and later find they have
cancer, a known paraneoplastic syndrome, or neurological problems that suggest a
paraneoplastic syndrome. Paraneoplastic syndromes are rare conditions in which the immune
system is involved in causing brain damage and fighting cancer.

Such patients with paraneoplastic neurologic degenerations(PNDs) may have autoantibodies, an
antibody or protein the immune system creates that is directed against his or her own
proteins. This study aims to better understand PNDS by:

- analyzing for autoantibodies in serum and cerebral spinal fluid

- analyzing for antigen specificity and for antigens in cancer tissue

- comparing PND autoantibodies with those in cancer patients but no PND

- comparing PND autoantibodies with those in PND patients but no cancer

- studying the immune performance of patients with PNDs

As this study is not a treatment study, tissues for this study will only come from
procedures necessary for the patient's treatment.


Inclusion Criteria:



- All adults are potentially eligible.

Exclusion Criteria:

- None.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Increase understanding of PNDS

Outcome Time Frame:

Ongoing

Safety Issue:

No

Principal Investigator

Jerome Posner, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

88-044

NCT ID:

NCT00587106

Start Date:

April 1988

Completion Date:

March 2009

Related Keywords:

  • Paraneoplastic Neurologic Degenerations (PNDs)
  • Paraneoplastic Syndromes

Name

Location

Memorial Sloan Kettering Cancer CenterNew York, New York  10021