Studies of Neurological Paraneoplastic Syndromes
Patients usually go to their doctors with neurological complaints and later find they have
cancer, a known paraneoplastic syndrome, or neurological problems that suggest a
paraneoplastic syndrome. Paraneoplastic syndromes are rare conditions in which the immune
system is involved in causing brain damage and fighting cancer.
Such patients with paraneoplastic neurologic degenerations(PNDs) may have autoantibodies, an
antibody or protein the immune system creates that is directed against his or her own
proteins. This study aims to better understand PNDS by:
- analyzing for autoantibodies in serum and cerebral spinal fluid
- analyzing for antigen specificity and for antigens in cancer tissue
- comparing PND autoantibodies with those in cancer patients but no PND
- comparing PND autoantibodies with those in PND patients but no cancer
- studying the immune performance of patients with PNDs
As this study is not a treatment study, tissues for this study will only come from
procedures necessary for the patient's treatment.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Increase understanding of PNDS
Ongoing
No
Jerome Posner, MD
Principal Investigator
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
88-044
NCT00587106
April 1988
March 2009
Name | Location |
---|---|
Memorial Sloan Kettering Cancer Center | New York, New York 10021 |