Cathartic-Free Dual Energy Computerized Tomography (DECT) Colonography.
Determine the feasibility to differentiate polyps from stool with or without the use of
contrast agents and to assess the feasibility and accuracy of dual energy techniques in a
pilot patient study.
1.1 Formulate algorithms that use dual-energy information to quantitatively measure specific
material density of colon polyps in physics based simulation.
1.2 Determine optimal scanning parameters on prototype CT equipment.
2.1 Measure the material composition density and Hounsfield number of polyps with and
without simulated contrast enhancement.
2.2 Measure the accuracy of dual-energy techniques to differentiate between polyps and
stool and if needed using a combination of simulated intravenous enhanced polyps and
contrast material tagged stool.
3.0 Asses the clinical performance of dual-energy CTC for the detection of larger polyps 1
cm or larger without cathartic preparation.
Observational Model: Cohort, Time Perspective: Prospective
Jeff L. Fidler, M.D.
United States: Food and Drug Administration
|Mayo Clinic||Rochester, Minnesota 55905|
|Mayo Clinic||Scottsdale, Arizona|