Trial Information

Photochemical Tissue Bonding (PTB) for Excisional Wound Healing

Hypertrophic scarring is a frequent endpoint after traditional surgical excision of skin
cancers of the chest. These scars create significant long-term morbidity to the patient.
There is a clinical need for an alternative treatment that would reduce factors associated
with hypertrophic and possibly keloid scar formation by providing minimal tension, low
infection risk and an absence of foreign body material. This would result in a normal
appearing and healed scar without associated patient morbidity. Photochemical tissue
bonding may provide this alternate treatment. PTB differs from sutures by continuously
joining the tissue surfaces on a molecular level rather than only at discrete suture points.
In addition, PTB does not incite foreign body reactions nor create tissue injury during
passage of the needle and tying a knot, injuries that may initiate scarring.