Genetic Studies in Breast Cancer
It is estimated that 175,000 new breast cancer cases and 44,5000 cancer deaths will result
from female breast cancer in 1991. One of the most important risk factors is a family
history of breast cancer. A susceptibility allele which accounts for a large proportion of
familial breast cancer has been localized to chromosome 17q and attempts to clone the
susceptibility are proceeding rapidly. The existence of recognized susceptibility loci and
the awareness of a significan proportion of genetic predisposition and the associated
penetrances remain unknown and are impossible to estimate without bias from previous
studies. This study is designed to estimate heterogeniety and prenetrance in a series of
unslected families, identify additional breast cancer susceptibility locs, as well as
provide resources for gene isolation and mutation analysis studies.
Observational
Observational Model: Case-Only, Time Perspective: Prospective
Teresa Gilewski, MD
Principal Investigator
Memorial Sloan-Kettering Cancer Center
United States: Food and Drug Administration
92-007
NCT00582322
February 1992
July 2009
Name | Location |
---|---|
Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |