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Genetic Studies in Breast Cancer

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Breast Cancer, Ovarian Cancer

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Trial Information

Genetic Studies in Breast Cancer

It is estimated that 175,000 new breast cancer cases and 44,5000 cancer deaths will result
from female breast cancer in 1991. One of the most important risk factors is a family
history of breast cancer. A susceptibility allele which accounts for a large proportion of
familial breast cancer has been localized to chromosome 17q and attempts to clone the
susceptibility are proceeding rapidly. The existence of recognized susceptibility loci and
the awareness of a significan proportion of genetic predisposition and the associated
penetrances remain unknown and are impossible to estimate without bias from previous
studies. This study is designed to estimate heterogeniety and prenetrance in a series of
unslected families, identify additional breast cancer susceptibility locs, as well as
provide resources for gene isolation and mutation analysis studies.

Inclusion Criteria:

- patient with breast cancer under age 41

- patient with bilateral breast cancer 41-50 years old or 41-50 years old with a first
degree relative (mother, sister, daughter) with breast cancer diagnosed under age 50

- patient with ovarian cancer with first degree relative with either ovarian cancer
diagnosed at any age or breast cancer diagnosed under age 60

- patient any age with either ovarian or breast cancer who have 2 first degree
rleatives with either ovarian cancer diagnosed at any age or breast cancer diagnosed
under age 50

- relatives of any of the above patients will be included in this trial if a genetic
abnormality is found in the patient's blood sample

Exclusion Criteria:


Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

Teresa Gilewski, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Food and Drug Administration

Study ID:




Start Date:

February 1992

Completion Date:

July 2009

Related Keywords:

  • Breast Cancer
  • Ovarian Cancer
  • Breast Cancer
  • Ovarian Cancer
  • Family History
  • Genetic Studies
  • Breast Neoplasms
  • Ovarian Neoplasms



Memorial Sloan-Kettering Cancer Center New York, New York  10021