Research on the Environment and Children's Health: Retinoblastoma
The purpose of the study is to investigate the role of paternal exposures in the etiology of
sporadic heritable retinoblastoma (RBL). The study has a matched case-control design with a
sample size of 255 pairs. Cases will be children with sporadic heritable (RBL) identified
from eight hospitals that together treat most of the RBL patients in the U.S. and Canada. We
will use regional controls matched on year of birth and state/province of residence
identified by randomdigit-dialing (RDD). Fathers and mothers of cases and controls will be
interviewed by telephone about their occupational, medical, dietary, and personal exposures
before the index child's conception. Blood samples will be obtained on cases and their
parents for DNA isolation. The case's DNA will be used to characterize the disease-causing
RB1 mutation. The parent's DNA will be used to detect the few instances in which a parent
also has the RB1 mutation, i.e., the child's RBL is familial rather than sporadic.
Observational
Observational Model: Case Control, Time Perspective: Prospective
demographic and exposure information by telephone interview
5 years 4 months
No
Ira Dunkel, MD
Principal Investigator
Memorial Sloan-Kettering Cancer Center
United States: Food and Drug Administration
03-030
NCT00582049
August 2003
June 2008
Name | Location |
---|---|
Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |