Optimized Intensity Modulated Irradiation for Head and Neck Cancer
Studies show that a dose response relationship in the salivary glands exists and that it may
be possible to improve significantly post-radiation xerostomia and quality of life if
radiation techniques can be devised that would spare the salivary glands while adequately
treating the targets. A new treatment modality (computer-optimized IMRT) facilitates
increased sparing of noninvolved tissue, specifically the sparing of both parotid glands,
and more conformal high-dose delivery to the bilateral neck targets in patients with head
and neck cancer. This study will evaluate the benefits regarding xerostomia-specific and
general QOL in patients receiving head and neck RT using this modality. Assessment of
swallowing dysfunction and aspiration will be made using videofluoroscopy. In addition, this
study will evaluate the pattern of local/regional tumor recurrence, to assess whether
sparing both parotid glands may cause tumor recurrence in spared neck areas.
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To objectively assess dysphagia and aspiration in patients receiving dysphagia/aspiration-sparing IMRT concurrent with chemotherapy.
United States: Institutional Review Board
|University of Michigan||Ann Arbor, Michigan 48109-0624|