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Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers

Phase 1/Phase 2
Open (Enrolling)
Breast Neoplasms, Ovarian Neoplasms, Colonic Neoplasms, Prostatic Neoplasms, Uterine Cervical Neoplasms, Leukemia, Lymphoma, Non-Hodgkin

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Trial Information

Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers

Patients can provide either a blood or saliva sample for the protocol. For blood samples,
two tubes of blood (approximately 20 cc) will be drawn from the patient, utilizing a sterile
technique. The tubes will be rocked so as to mix the blood with the additive (EDTA) in the
tubes. For saliva samples, approximately 2-4 ml of saliva will be collected in specialized
Oragene DNA Self-Collection Kit tubes.

Inclusion Criteria:

- Patients accepted for referral to the Cancer Family Clinic of the Department of
Medicine at Memorial Sloan-Kettering Cancer Center are eligible for participation in
this study. Such patients should have a history of cancers of the breast, ovary,
colon, prostate, uterus, non-Hodgkin's lymphoma, leukemia, soft tissue sarcoma,
endocrine neoplasms, or other malignancies presenting in first degree relatives or in
successive generations as part of a suspected cancer family syndrome.

- Family members of probands including parents, sisters, brothers, half-brothers and
sisters, sons, daughters, grandparents, as well as aunts and uncles are also

- This study involves research which presents no greater than minimal risk to children.
The assent of any minor should be obtained before the patient is entered into this

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

To establish a bank of DNA and frozen lymphoblastoid cell lines for the purpose of facilitating genetic epidemiology investigations of familial cancers.

Outcome Time Frame:

1 year

Safety Issue:


Principal Investigator

Kenneth Offit, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

December 1994

Completion Date:

December 2013

Related Keywords:

  • Breast Neoplasms
  • Ovarian Neoplasms
  • Colonic Neoplasms
  • Prostatic Neoplasms
  • Uterine Cervical Neoplasms
  • Leukemia
  • Lymphoma, Non-Hodgkin
  • Blood
  • Salvia
  • Tissue
  • Breast Neoplasms
  • Neoplasms
  • Uterine Cervical Neoplasms
  • Colonic Neoplasms
  • Leukemia
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Ovarian Neoplasms
  • Prostatic Neoplasms



Memorial Sloan-Kettering Cancer Center New York, New York  10021