Inclusion Criteria:

- Patients with severe HOMOZYGOUS SICKLE CELL ANEMIA or SICKLE/BETA THALASSEMIA

- Neurologic event (stroke or hemorrhage).

- Abnormal cerebral MRI scan and cerebral arteriogram or MRI angiographic study (MRA)
and impaired neuropsychologic testing.

- Recurrent acute chest syndrome (> 2 episodes)

- Stage I-II sickle chronic lung disease

- Sickle cell nephropathy (moderate or severe proteinuria or GFR 30-50% of predicted
for age.

- Major visual impairment in at least one eye with bilateral proliferative retinopathy.

- Osteonecrosis of multiple bones

- Chronic debilitating pain secondary to vasoocclusive crisis (>= 3 episodes per year
for >= 3 years) Recurrent priapism

- Allo-immunization with the development of antibodies following chronic transfusion
therapy

- Patients with HOMOZYGOUS SICKLE CELL ANEMIA or SICKLE/BETA THALASSEMIA with the
following criteria will be considered for accrual on this protocol

- Patients < 2 years with high WBC counts and/or >1 episode of dactylitis and/or a Hgb
< 7 g/dl

- History of death from sickle cell disease in sibship of patient

- Patients with BETA-THALASSEMIA MAJOR with Lucarelli class 1 or 2 risk status i.e with
only 0-2 of the following factors: hepatomegaly, portal fibrosis, or poor chelation
therapy

- Patients with DIAMOND-BLACKFAN ANEMIA who have failed conventional therapy.

- Patients must have an HLA-compatible related donor. The donor must be healthy and
able to undergo general anesthesia. Donors with heterozygous sickle cell anemia
(hemoglobin AS) or with heterozygous thalassemia are acceptable donors.

- At the time of referral for transplantation, patients must be in good clinical
condition without any evidence of infections and a Karnofsky or Lansky pediatric
performance scale > 70%

- Each patient and donor must be willing to participate as a research subject and must
sign an informed consent form after having been advised as to the nature and risk of
the study prior to entering the protocol. Parents or legal guardians of patients who
are minor will sign the consent form after being advised of the nature and risks of
the study

Exclusion Criteria:

- Patients whose life expectancy is less than 8 weeks. Patients with a Karnofsky or
Lansky performance score of < 70%

- Patients with severe major organ dysfunction:

- Patients with severe renal impairment. This will be determined by a creatinine
clearance < 70 ml/min/1.73 m2 (or serum creatinine > 1.5 x Normal) or by a glomerular
filtration rate < 30% of predicted normal for age

- Inadequate cardiac function as determined by fractional shortening < 28% on
echocardiogram, and/or ejection fraction of < 50% on echocardiogram or RNCA.

- Patients with FS of 23-28% who show an increase in FS in response to stress on the
supine bicycle ergometer are eligible

- Major liver dysfunction: SGOT > 3 x upper limit of normal. Hyperbilirubinemia will
not be used as an exclusion criteria because of the hemolytic component of the
bilirubin. Patients with active hepatitis or severe liver fibrosis will also be
excluded

- Severe residual functional neurologic impairment

- Stage III-IV sickle chronic lung disease

- Pregnant or lactating women are excluded