CNS Targets of Propofol's Hypnotic and Memory Effects
We wish to seek evidence of a neuroanatomical basis for the separation of the
sedative/hypnotic and amnesic effects of propofol by imaging electrophysiologic and regional
cerebral blood flow (rCBF) changes to identify these. Our main hypothesis is that there are
differing neuroanatomical regions mediating drug-induced sedation and amnesia, and that
these can be identified by specific changes in electrophysiology and rCBF.
Electrophysiologic changes will be mapped using a validated electroencephalographic (EEG)
mapping technique, Low Resolution brain Electromagnetic Tomography (LORETA). (1) Changes in
brain activity will be identified with high spatial resolution using magnetic resonance
imaging (MRI) and statistical parametric mapping (SPM). (2) To identify key regions out of
possibly many exhibiting changes in brain activity during propofol administration, we plan
to manipulate drug-induced sedation by using thiopental, a sedative drug with few memory
effects active at the same receptors as propofol.
Observational Model: Case Control, Time Perspective: Prospective
Demonstrate the persistence of defined stimulation-related changes in brain activity during various levels of propofol and thiopental sedation.
fifteen hours over several different days
Robert Veselis, MD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
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