Inclusion Criteria:

- adult patients, >=18 years of age;

- liver cancer, not suitable for resection;

- at least one measurable lesion, and overall tumor lesions occupying <50% of liver
volume;

- ECOG performance status 0-2.

Exclusion Criteria:

- patients receiving concurrent radiotherapy or immunotherapy;

- patients who have received previous chemotherapy, biological agents or radiotherapy;

- prior TACE or TAE;

- prior liver transplantation or liver resection;

- current or recent (within 10 days of study start) use of full-dose anticoagulants for
therapeutic purposes;

- patients with high risk esophageal/gastric varices.