Concurrent Chemo-Radiotherapy for Limited Disease Small Cell Lung Cancer (LD-SCLC) on Basis of FDG-PET-Scans
Eligible patients (see below) will receive radiotherapy to the primary tumor and the
initially involved mediastinal lymph nodes on FDG-PET scan to a dose of 45 Gy in 30
fractions in 3 weeks (1.5 Gy BID with minimum 6 h interfraction interval).
Dose-constraints: MLD > 20 Gy. In that case, CT-based replanning will be done after 1 week
of treatment and shrinking field techniques will be used if appropriate.
The radiation doses will be specified according to ICRU 50. Lung density corrections will be
applied, as well as all standard QA procedures. Technical requirements are the same as in
standard practice at MAASTRO clinic.
Radiotherapy shall start during the first cycle of carboplatin and etoposide chemotherapy.
Chemotherapy (standard schedule in the Comprehensive Cancer Centre Limburg region):
- carboplatin AUC 5 day 1
- etoposide 120 mg/m2 days 1-3
Q 3 weeks; 5 cycles
In patients with no progression and a WHO PS 0-2, after the completion of chemotherapy, PCI
will be given (25 Gy in 10 fractions, QD)
Observational Model: Cohort, Time Perspective: Prospective
isolated Nodal Recurrences
18 months post-treatment
Dirk De Ruysscher, MD,PhD
MAASTRO clinic, Maastricht Radiation Oncology
Netherlands:Board MAASTRO clinic
BRONC 45, 1.5