Molecular Analysis of Breast Cancer
The tissue obtained in this protocol will be used for genome-wide examination of DNA, RNA
expression profiling, proteomic analyses, isolation and analyses of normal and cancer stem
cells, isolation and analyses of circulating tumor cells, possible analyses of immune cells,
and possible analyses of serum factors. The tissue may also be used to develop
patient-specific cell culture models or mouse xenograft models of breast cancer for biologic
study of tumor progression and metastases and for therapeutic testing. In general, the
tissue will be used in studies that will molecularly classify tumors, identify prognostic
markers, identify potential therapeutic markers, identify potential treatment targets, and
help us better understand the biology and specific role played by different tumor cells in
the metastatic process.
The ultimate goal is to use molecular analyses to improve the diagnosis and treatment of
Observational Model: Cohort, Time Perspective: Prospective
Stefanie S. Jeffrey M.D.
United States: Food and Drug Administration
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