Inclusion Criteria:

- All patients must have histologically proven adenocarcinoma of the prostate

- The primary tumour should be staged clinically B2 or C as classified by A.J.C.
Staging System

Exclusion Criteria:

- Patients requiring transurethral prostatectomy (TURP) prior to diagnosis

- Presence of metastases identified by bone scan, chest x-ray or CT scan of the abdomen
and pelvis, or staging lymphadenectomy

- Karnofsky performance status less than 80

- Inadequate laboratory results: i.e. Hb < 12 gm/litre, WBC < 3.5 x 10 per litre,
platelets < 100 x 10/litre, urea > 13 mmol/litre, creatinine > 220 mmol/litre

- Unfit for surgery for other medical reasons

- Age above 75 years

- Failure to provide written informed consent