Inclusion Criteria:

- Participant has a histologically-confirmed metastatic or locally advanced solid tumor
that has failed to respond to standard therapy or progressed with standard therapy

Exclusion Criteria:

- Participant has had chemotherapy, radiotherapy or biological therapy within 4 weeks
prior to study start or has not recovered from adverse events caused by therapy more
than 4 weeks earlier

- Participant is currently participating or has participated in a study with an
investigational compound or device within 4 weeks prior to signing informed consent

- Participant has received more than 2 courses of chemotherapy for metastatic disease

- Participant has had prolonged neutropenia or neutropenia with fever from previous
chemotherapy treatment

- Participant has a primary central nervous system tumor

- Participant is a regular or recreational user of any illicit drugs or has a recent
history within the last year of drug or alcohol abuse

- Participant is pregnant, breastfeeding or planning to have children during the study

- Participant is Human Immunodeficiency Virus (HIV) positive

- Participant has a history of Hepatitis B or C