Inclusion Criteria:

- Histological confirmed Non-Small Cell Lung Cancer that can not be treated within a
defined radiological field

- Tumor stage IIIB (pleural effusion or pericardial effusion included) or IV

- The following histological tumor types are eligible:

- Adenocarcinoma (including adenocarcinomas with bronchioloalveolar
differentiation)

- Large Cell Carcinoma (including large cell carcinomas with neuroendocrine
differentiation)

- Mixed Cell Carcinoma without small cell fraction and without predominant
squamous cell fraction (< 50%)

- undifferentiated non-small-cell-carcinoma

- No previous chemotherapy within the last five years

- At least 4 weeks since last major surgery

- Age ≥ 18 years

- ECOG <= 2

- Adequate hematological laboratory parameters

- Hemoglobin ≥ 10 g/dl

- WBC ≥ 3.000/µl

- Platelets ≥ 100.000/µl

- Adequate hepatic laboratory parameters

- Bilirubin <= 2,0 mg/dl

- AST(GOT) <= 2,5 x ULN in patients without liver metastases

- AST(GOT) <= 5 x UNL in patients with liver metastases

- ALT(GPT) <= 2,5 x ULN in patients without liver metastases

- ALT(GPT) <= 5 x UNL in patients with liver metastases

- Adequate renal laboratory parameters

- Creatinine <= 1,5 mg/dl

- Creatinine Clearance > 60 ml/min

- Adequate plasmatic blood coagulation - INR <= 1,5 and PTT <= 1,5 x ULN

- Normal cardiac function defined by LVEF > 49% (echocardiography)

- Electrocardiogram without significant signs of cardiac arrhythmias

- Provision of informed consent according to local regulatory requirements prior to any
protocol specific treatment

- Measurable lesion according to RECIST-Criteria's

- Negative pregnancy test for women of childbearing potential unless they are
postmenopausal at baseline. (Postmenopausal women must have been amenorrheic at least
for 12 months to be considered of non childbearing potential)

- Women of child bearing potential to must be willing to use an acceptable method to
avoid pregnancy at least one month before study start. Examples: oral contraceptives
(sole application of oral contraceptives is not sufficient), diaphragm pessary,
intrauterine device (spiral), condom plus diaphragm pessary plus spermicide

Exclusion Criteria:

- Histologic confirmed squamous cell carcinoma

- Pregnancy or lactation period

- Tumor extension treatable with radiotherapy

- Current clinical signs or symptoms of brain and/or leptomeningeal metastases
confirmed by CT or MRI brain scan

- Evidence of tumor invading or abutting major blood vessels

- Other co-existing malignancies or malignancies diagnosed within the last 5 years with
the exception of a CIS of the cervix or non-melanomatous skin cancer. Patients
curatively treated and free of disease for at least 5 years will be discussed with
the Principal Investigator (LKP) before inclusion

- Any previous chemotherapy within the last five years

- Any radiotherapy with exception of the following situations:

- concomitant small field radiotherapy in the case of solitary bone metastases
or other solitary metastases

- in case of large field radiotherapy or multi-radiation fields due to multiple
bone metastases or other metastases. The application of study medication then
must be delayed at least for 24 h (after last radiotherapy)

- in case of radiotherapy of the primary tumor trial therapy can be employed if
radiotherapy has ended at least 6 weeks ago and new tumor progression is clearly
documented

- Treatment with an investigational new drug, currently or within the last 28 days,
and/or participation in another clinical trial, currently or during the last 12
weeks, and/or previous participation in this study

- A history or presence of any CNS disorder or psychiatric disability judged by the
Investigator to be clinically significant and/or interfering with compliance of oral
drug intake

- Patients with any clinically significant disease that in the opinion of the
investigator is likely to put the patient at risk or to interfere with the evaluation
of the patient's safety and of the study outcome. This includes, but is not limited
to:

- Any known significant ophthalmologic abnormalities of the surface of the eye
(the use of contact lenses is not recommended)

- Immediate need for therapeutic intervention (e.g.: upper inflow congestion or
poststenotic pneumonia)

- Clinically significant cardiac disease (e.g. right-sided heart failure,
symptomatic coronary artery disease and cardiac arrhythmias not well controlled
with medication) or myocardial infarction within the last 6 months

- pleural effusion or pericardial effusion with the need for intervention

- Uncontrolled hypertension

- Non healing wound, ulcer or bone fracture

- Fresh thrombosis under therapy with anticoagulants

- Hemorrhagic diathesis, Hemophilia A, Hemophilia B

- Implantation of a central vein catheter (Prot-Catheter) within 24 h prior to
application of study medication

- Present hemoptysis of any CTC grade or history of hemoptysis of any CTC grade within
3 month prior to study start

- Peritoneal carcinomatosis

- History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess
within 6 month prior to study start

- Interstitial pneumonia or extensive or symptomatic interstitial fibrosis of the lung

- Pleural effusion or ascites, which cause respiratory compromise

- Any other active or uncontrolled infection

- Organ allograft

- History of a mental disease or condition such as to interfere with the patient's
ability to understand the requirements of the study and the intake of study
medication according to study protocol

- Inability to swallow pills

- Current or recent (within 10 days of first dose of study medication) use of
coumadin/warfarin or marcumar/phenprocoumon for therapeutic purposes Prophylactic use
of low molecular weight heparins is allowed

- Current or recent (within 10 days of first dose of study medication) use of ASS -
Dosage > 325 mg/day

- Current or recent (within 10 days of first dose of study medication) use of
Plavix/Clopidogrel

- Alcohol and drug abuse

- Known hypersensitivity to any of the study drugs

- Presence of a tracheobronchial fistula or fistulization in other organ systems like
gastrointestinal fistulas or fistulization of urogenital tract