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A Randomized Phase III Double-Blind Placebo-Controlled Trial of First-Line Chemotherapy and Trastuzumab With or Without Bevacizumab for Patients With HER-2/NEU Over-Expressing Metastatic Breast Cancer

Phase 3
18 Years
Open (Enrolling)
HER2-positive Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer

Thank you

Trial Information

A Randomized Phase III Double-Blind Placebo-Controlled Trial of First-Line Chemotherapy and Trastuzumab With or Without Bevacizumab for Patients With HER-2/NEU Over-Expressing Metastatic Breast Cancer


I. Evaluate efficacy of the addition of bevacizumab in patients eligible for first-line
trastuzumab with chemotherapy for HER-2/NEU overexpressing metastatic breast cancer, by
assessing the progression-free survival (PFS) after initiation of combination therapy.


I. Evaluate response rates (RR) in patients with measurable disease (RECIST), when

II. Evaluate overall survival (OS). III. Evaluate time to progression (TTP). IV. Evaluate
the percent of patients who are progression-free (PPF) at 6 months.

V. Compare the toxicity of chemotherapy/trastuzumab to that of chemotherapy/ trastuzumab in
combination with bevacizumab.

VI. Compare breast cancer symptoms and treatment related symptoms between patients receiving
chemotherapy and trastuzumab with or without bevacizumab.

VII. Evaluate whether PFS correlates with VEGF levels in breast tumor tissue. VIII. Analysis
of Circulating Tumor Cells and Circulating Endothelial Cells (CEC).

IX. Serially enumerate CTC and CEC in patients on study and determine whether: The number of
CTC and CEC decrease in responding patients; the extent of CTC and CEC decrease is greater
in the experimental arm, Arm B versus the control arm, Arm A; enumeration of CTC and CEC in
responding patients correlate with progression free survival (PFS).

X. Perform an exploratory analysis of phosphorylation status of akt-2 in circulating tumor

XI. Perform an exploratory analysis of RT-PCR of CTC mRNA to determine whether change in
expression of selected down stream targets of bevacizumab therapy can serve as
pharmacodynamic or surrogate markers of bevacizumab targeting and modulation.

OUTLINE: This is a multicenter study. Patients are stratified according to prior treatment
with adjuvant trastuzumab (Herceptin) (yes vs no), prior treatment with neoadjuvant or
adjuvant taxane (yes vs no), disease-free interval (> 24 months vs =< 24 months), and
planned treatment with carboplatin (yes vs no). Patients are randomized to 1 of 2 treatment


INDUCTION THERAPY: Patients receive trastuzumab intravenously (IV) over 30-90 minutes on
days 1, 8, 15, and 22 and paclitaxel IV over 60 minutes with or without carboplatin IV over
60 minutes on days 1, 8, and 15. Patients also receive placebo IV over 30-90 minutes on day
1 and 15. Treatment repeats every 4 weeks for 6 courses in the absence of disease
progression or unacceptable toxicity.

MAINTENANCE THERAPY: Beginning 1 week after the last dose of induction trastuzumab, patients
receive trastuzumab IV over 30-90 minutes and placebo IV over 30-90 minutes on day 1.
Treatment repeats every 3 weeks in the absence of disease progression or unacceptable


INDUCTION THERAPY: Patients receive trastuzumab and paclitaxel with or without carboplatin
as in arm A. Patients also receive bevacizumab IV over 30-90 minutes on days 1 and 15.
Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or
unacceptable toxicity.

MAINTENANCE THERAPY: Beginning 1 week after the last dose of induction trastuzumab, patients
receive trastuzumab IV over 30-90 minutes and bevacizumab IV over 30-90 minutes on day 1.
Treatment repeats every 3 weeks in the absence of disease progression or unacceptable

After completion of study treatment, patients are followed periodically for 10 years.

Inclusion Criteria:

- ECOG performance status of 0 or 1

- Histologically confirmed breast cancer that overexpresses HER-2/NEU

- HER-2/NEU overexpression is defined as 3+ HER-2 positivity as measured by
immunohistochemistry OR HER-2 gene amplification as measured by FISH

- Evidence of metastatic disease and/or chest wall recurrence

- Evaluable (measurable or non-measurable) disease is allowed if confirmed within 4
weeks prior to study randomization

- No history or radiologic evidence of CNS disease

- Platelet count >= 100,000/mm^3

- Total bilirubin =< 1.5 mg/dL

- AST =< 2 times upper limit of normal (ULN) (=< 5 times normal in patients with known
liver involvement)

- Serum creatinine =< 1.5 mg/dL

- Urine protein:creatinine ratio =< 0.5 OR 24-hour urine protein < 1,000 mg

- INR =< 1.5 times ULN

- PTT =< 1.5 times ULN

- LVEF above the lower limit of normal by MUGA scan or ECHO

- No grade 2-4 neuropathy

- No unstable angina pectoris

- No serious cardiac arrhythmia requiring medication

- No clinically significant peripheral vascular disease

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No current non-healing wound or fracture

- No hypersensitivity to Chinese hamster ovary cell products or other recombinant human
antibodies, paclitaxel, or drugs using the vehicle Cremophor

- No serious medical or psychiatric illness that would preclude study participation

- No other active malignancy within the past 5 years except carcinoma in situ of the
cervix or nonmelanoma skin cancer

- Adjuvant or neoadjuvant taxane therapy for breast cancer is allowed provided last
dose was given >= 12 months prior to diagnosis of recurrence

- No prior chemotherapy, trastuzumab, or bevacizumab for metastatic breast cancer

- No prior cumulative dose of doxorubicin hydrochloride > 360 mg/m2 or epirubicin
hydrochloride > 640 mg/m2 (in the neoadjuvant or adjuvant setting)

- More than 4 weeks since prior major surgical procedure (except for non-operative

- More than 7 days since prior placement of a vascular access device

- Concurrent full-dose anticoagulants (e.g., warfarin) with PT/INR > 1.5 allowed
provided the following criteria are met:

- In-range INR (usually between 2 and 3) on a stable dose of oral anticoagulant or on a
stable dose of low molecular weight heparin

- No active bleeding or pathological condition that carries a high risk of bleeding
(e.g., tumor involving major vessels or known varices)

- No concurrent local radiotherapy for pain control or life-threatening situations

- No concurrent drugs known to inhibit platelet function, including the following:

- dipyridamole,

- ticlopidine,

- clopidogrel,

- cilostazol

- Adjuvant trastuzumab (Herceptin) therapy for breast cancer is allowed provided last
dose was given >= 12 months prior to diagnosis of recurrence

- Adjuvant or neoadjuvant therapy with lapatinib ditosylate is allowed provided last
dose was given >= 4 weeks prior to diagnosis of recurrence

- Absolute neutrophil count >= 1,000/mm^3

- No clinically significant cardiovascular disease

- No cerebrovascular accident within the past 6 months

- No myocardial infarction or unstable angina within the past 6 months

- No New York Heart Association class II-IV congestive heart failure

- No uncontrolled hypertension

- Endocrine treatment in the adjuvant or metastatic setting is allowed, provided last
dose given >= 2 weeks prior to randomization

- More than 3 weeks since prior radiotherapy

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

Progression-free survival

Outcome Description:

This primary comparison will be performed using a one-sided log rank test stratified using an overall type I error of 2.5%.

Outcome Time Frame:

From randomization to progression per RECIST, new second breast cancer primaries or to death from any cause without documentation of progression, whichever occurs first, assessed up to 10 years

Safety Issue:


Principal Investigator

Ingrid Mayer

Investigator Role:

Principal Investigator

Investigator Affiliation:

Eastern Cooperative Oncology Group


United States: Food and Drug Administration

Study ID:




Start Date:

November 2007

Completion Date:

Related Keywords:

  • HER2-positive Breast Cancer
  • Male Breast Cancer
  • Recurrent Breast Cancer
  • Stage IV Breast Cancer
  • Breast Neoplasms
  • Breast Neoplasms, Male



Albert Einstein College of Medicine Bronx, New York  10461
Roswell Park Cancer Institute Buffalo, New York  14263
Mayo Clinic Rochester, Minnesota  55905
Washington University School of Medicine Saint Louis, Missouri  63110
University of Washington Medical Center Seattle, Washington  98195-6043
Hurley Medical Center Flint, Michigan  48503
Boulder Community Hospital Boulder, Colorado  80301-9019
Porter Adventist Hospital Denver, Colorado  80210
Rose Medical Center Denver, Colorado  80220
Swedish Medical Center Englewood, Colorado  80110
Sky Ridge Medical Center Lone Tree, Colorado  80124
North Suburban Medical Center Thornton, Colorado  80229
Fairview Ridges Hospital Burnsville, Minnesota  55337
Hutchinson Area Health Care Hutchinson, Minnesota  55350
Meeker County Memorial Hospital Lichfield, Minnesota  55355
United Hospital St. Paul, Minnesota  55102
Ridgeview Medical Center Waconia, Minnesota  55387
Morristown Memorial Hospital Morristown, New Jersey  07962-1956
Ingalls Memorial Hospital Harvey, Illinois  60426
Methodist Medical Center of Illinois Peoria, Illinois  61636
Memorial Hospital of South Bend South Bend, Indiana  46601
Mary Bird Perkins Cancer Center Baton Rouge, Louisiana  70809
Grand View Hospital Sellersville, Pennsylvania  18960
Virginia Piper Cancer Institute Minneapolis, Minnesota  55407
Eastern Maine Medical Center Bangor, Maine  04401
Camden-Clark Memorial Hospital Parkersburg, West Virginia  26102
Via Christi Regional Medical Center Wichita, Kansas  67214
Scott and White Memorial Hospital Temple, Texas  76508
Iowa Methodist Medical Center Des Moines, Iowa  50309
Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Cape Fear Valley Health System Fayetteville, North Carolina  28302-2000
Group Health Cooperative Seattle, Washington  98112
University of Wisconsin Hospital and Clinics Madison, Wisconsin  53792-0001
Great Falls Clinic Great Falls, Montana  59405
Overlook Hospital Summit, New Jersey  07902-0220
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington  98109
Montefiore Medical Center Bronx, New York  10467-2490
North Colorado Medical Center Greeley, Colorado  80631
McKee Medical Center Loveland, Colorado  80539
Cancer Center of Kansas - Chanute Chanute, Kansas  66720
Cancer Center of Kansas - Dodge City Dodge City, Kansas  67801
Cancer Center of Kansas - Newton Newton, Kansas  67114
Cancer Center of Kansas - Salina Salina, Kansas  67042
Cancer Center of Kansas - Wellington Wellington, Kansas  67152
Associates in Womens Health Wichita, Kansas  67203
Cancer Center of Kansas - Winfield Winfield, Kansas  67156
Northern Rockies Radiation Oncology Center Billings, Montana  59101
Bozeman Deaconess Hospital Bozeman, Montana  59715
Kalispell Medical Oncology Kalispell, Montana  59901
Kalispell Regional Medical Center Kalispell, Montana  59901
Adena Regional Medical Center Chillicothe, Ohio  54601
Grady Memorial Hospital Delaware, Ohio  43015
Fairfield Medical Center Lancaster, Ohio  43130
Harborview Medical Center Seattle, Washington  98104
Cancer Care Northwest - Spokane South Spokane, Washington  99202
Welch Cancer Center Sheridan, Wyoming  82801
Elkhart General Hospital Elkhart, Indiana  46515
South Bend Clinic South Bend, Indiana  46617
Saint Rose Hospital Hayward, California  94545
Alta Bates Summit Medical Center - Summit Campus Oakland, California  94609
Memorial Hospital Carthage, Illinois  62321
Hematology and Oncology Associates Chicago, Illinois  60611
Galesburg Cottage Hospital Galesburg, Illinois  61401
Galesburg Clinic Galesburg, Illinois  61401
Mason District Hospital Havana, Illinois  62644
McDonough District Hospital Macomb, Illinois  61455
BroMenn Regional Medical Center Normal, Illinois  61761
Proctor Hospital Peoria, Illinois  61614
Perry Memorial Hospital Princeton, Illinois  61356
Genesis Medical Center - West Campus Davenport, Iowa  52804
Community Cancer Center of Monroe Monroe, Michigan  48162
Bismarck Cancer Center Bismarck, North Dakota  58501
Grandview Hospital Dayton, Ohio  45405
Lima Memorial Hospital Lima, Ohio  45804
Mercy Medical Center Springfield, Ohio  45504
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Fulton County Health Center Wauseon, Ohio  43567
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Danville Regional Medical Center Danville, Virginia  24541
Exempla Lutheran Medical Center Wheat Ridge, Colorado  80033
Eureka Hospital Eureka, Illinois  61530
Mercy Hospital Coon Rapids, Minnesota  55433
Graham Hospital Association Canton, Illinois  61520
Holy Family Medical Center Des Plaines, Illinois  60016
Hematology Oncology Associates of Illinois-Highland Park Highland Park, Illinois  60035
Saint Joseph Medical Center Joliet, Illinois  60435
Pekin Hospital Pekin, Illinois  61554
Medical Oncology and Hematology Associates Des Moines, Iowa  50309
Bixby Medical Center Adrian, Michigan  49221
Saint Joseph Mercy Hospital Ann Arbor, Michigan  48106
Fairview-Southdale Hospital Edina, Minnesota  55435
Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Regions Hospital Saint Paul, Minnesota  55101
Saint Francis Regional Medical Center Shakopee, Minnesota  55379
Saint Luke's Hospital Maumee, Ohio  43537
Lancaster General Hospital Lancaster, Pennsylvania  17604-3555
Highland General Hospital Oakland, California  94602
Pomona Valley Hospital Medical Center Pomona, California  91767
Center for Cancer Care and Research St. Louis, Missouri  63141
Miami Valley Hospital Dayton, Ohio  45409
Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut  06360
Hospital District Sixth of Harper County Anthony, Kansas  67003
Cancer Center of Kansas - Fort Scott Fort Scott, Kansas  66701
Cancer Center of Kansas-Independence Independence, Kansas  67301
Lawrence Memorial Hospital Lawrence, Kansas  66044
Bozeman Deaconess Cancer Center Bozeman, Montana  59715
Northern Montana Hospital Havre, Montana  59501
Mary Rutan Hospital Bellefontaine, Ohio  43311
Wayne Hospital Greenville, Ohio  45331
Clinton Memorial Hospital Wilmington, Ohio  45177
Adventist Medical Center Portland, Oregon  97216
Marshfield Clinic Cancer Care at Regional Cancer Center Eau Claire, Wisconsin  54701
UW Cancer Center Johnson Creek Johnson Creek, Wisconsin  53038
Saint Joseph's Hospital Marshfield, Wisconsin  54449
Diagnostic and Treatment Center Weston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin  54494
Longmont United Hospital Longmont, Colorado  80501
Baton Rouge General Medical Center Baton Rouge, Louisiana  70821-2511
Zale Lipshy University Hospital Dallas, Texas  75235-7786
Greene Memorial Hospital Xenia, Ohio  45385
Greater Baltimore Medical Center Baltimore, Maryland  21204
Memorial Medical Center Springfield, Illinois  62781
Doylestown Hospital Doylestown, Pennsylvania  18901
Guardian Oncology and Center for Wellness Missoula, Montana  59804
Queen's Medical Center Honolulu, Hawaii  96813
Woodwinds Health Campus Woodbury, Minnesota  55125
Vanderbilt University Nashville, Tennessee  37232-6305
Northwestern University Chicago, Illinois  60611
Cancer Care Associates Tulsa, Oklahoma  74136
East Bay Radiation Oncology Center Castro Valley, California  94546
Contra Costa Regional Medical Center Martinez, California  94553-3156
Larry G Strieff MD Medical Corporation Oakland, California  94609
Hennepin County Medical Center Minneapolis, Minnesota  
University of Rochester Rochester, New York  14642
El Camino Hospital Mountain View, California  94040
Case Western Reserve University Cleveland, Ohio  44106
Emory University Atlanta, Georgia  30322
Wayne State University Detroit, Michigan  48202
Riverside Methodist Hospital Columbus, Ohio  43214
Licking Memorial Hospital Newark, Ohio  43055-2899
Providence Portland Medical Center Portland, Oregon  97213-3635
Mid Dakota Clinic Bismarck, North Dakota  58501
Columbus CCOP Columbus, Ohio  43206
Indiana University Medical Center Indianapolis, Indiana  46202
Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado  80218
University of Texas Southwestern Medical Center Dallas, Texas  
Wichita CCOP Wichita, Kansas  67214-3882
Montana Cancer Consortium CCOP Billings, Montana  59101
Flower Hospital Sylvania, Ohio  43560-2197
Metro-Minnesota CCOP St. Louis Park, Minnesota  
UC Davis Comprehensive Cancer Center Sacramento, California  95817
Decatur Memorial Hospital Decatur, Illinois  62526
Louisiana State University Health Science Center New Orleans, Louisiana  70112
Montana Cancer Specialists Missoula, Montana  59807-7877
Memorial Health University Medical Center Savannah, Georgia  31404
Northern Indiana Cancer Research Consortium South Bend, Indiana  
Hawaii Medical Center East Honolulu, Hawaii  96817
OSF Saint Francis Medical Center Peoria, Illinois  61637
Valley Medical Oncology Consultants-Castro Valley Castro Valley, California  94546
Eden Hospital Medical Center Castro Valley, California  94546
Valley Medical Oncology Consultants-Fremont Fremont, California  94538
Fremont - Rideout Cancer Center Marysville, California  95901
Community Hospital of Monterey Peninsula Monterey, California  93940
Bay Area Breast Surgeons Inc Oakland, California  94609
Bay Area Tumor Institution CCOP Oakland, California  94609
Tom K Lee Inc Oakland, California  94609
Valley Medical Oncology Consultants Pleasanton, California  94588
Valley Care Health System - Pleasanton Pleasanton, California  94588
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo, California  94806
The Medical Center of Aurora Aurora, Colorado  80012
Penrose-Saint Francis Healthcare Colorado Springs, Colorado  80907
Saint Anthony Central Hospital Denver, Colorado  80204
Exempla Saint Joseph Hospital Denver, Colorado  80218
Colorado Cancer Research Program CCOP Denver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical Center Grand Junction, Colorado  81502
Saint Mary Corwin Medical Center Pueblo, Colorado  81004
Saint Joseph's-Candler Health System Savannah, Georgia  31405
University of Hawaii Honolulu, Hawaii  96813
Rush - Copley Medical Center Aurora, Illinois  60504
John H Stroger Jr Hospital of Cook County Chicago, Illinois  60612-3785
Evanston CCOP-NorthShore University HealthSystem Evanston, Illinois  60201
Hopedale Medical Complex - Hospital Hopedale, Illinois  61747
Joliet Oncology-Hematology Associates Limited Joliet, Illinois  60435
Midwest Center for Hematology Oncology Joliet, Illinois  60432
North Shore Hematology Oncology Libertyville, Illinois  60048
Stoffel, Thomas J MD (UIA Investigator) Moline, Illinois  61265
Garneau, Stewart C MD (UIA Investigator) Moline, Illinois  61265
Sharis, Christine M MD (UIA Investigator) Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator) Moline, Illinois  61265
Community Cancer Center Foundation Normal, Illinois  61761
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois  61350
Ottawa Regional Hospital and Healthcare Center Ottawa, Illinois  61350
Pekin Cancer Treatment Center Pekin, Illinois  61554
Illinois Oncology Research Association CCOP Peoria, Illinois  61615
Illinois CancerCare-Peoria Peoria, Illinois  61615
Illinois Valley Hospital Peru, Illinois  61354
Hematology Oncology Associates of Illinois - Skokie Skokie, Illinois  60076
Saint Margaret's Hospital Spring Valley, Illinois  61362
Carle Clinic-Urbana Main Urbana, Illinois  61801
Saint Francis Hospital and Health Centers Beech Grove, Indiana  46107
Wishard Hospital Indianapolis, Indiana  46202
Saint Vincent Hospital and Health Services Indianapolis, Indiana  46260
Saint Anthony Memorial Health Center Michigan City, Indiana  46360
Reid Hospital and Health Care Services Richmond, Indiana  47374
McFarland Clinic Ames, Iowa  50010
Constantinou, Costas L MD (UIA Investigator) Bettendorf, Iowa  52722
Genesis Medical Center - East Campus Davenport, Iowa  52803
Iowa Oncology Research Association CCOP Des Moines, Iowa  50309
Mercy Capitol Des Moines, Iowa  50307
Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des Moines Des Moines, Iowa  50309
Mercy Medical Center-Sioux City Sioux City, Iowa  51104
Saint Luke's Regional Medical Center Sioux City, Iowa  51104
Covenant Medical Center Waterloo, Iowa  50702
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Cancer Center of Kansas-Kingman Kingman, Kansas  67068
Cancer Center of Kansas - Parsons Parsons, Kansas  67357
Cancer Center of Kansas - Pratt Pratt, Kansas  67124
Stormont-Vail Regional Health Center Topeka, Kansas  66604
Saint Francis Hospital and Medical Center - Topeka Topeka, Kansas  66606
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas - Main Office Wichita, Kansas  67214
Medical Center of Louisiana New Orleans, Louisiana  70112
Hickman Cancer Center Adrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor, Michigan  48106
Oakwood Hospital Dearborn, Michigan  48123
Saint John Hospital and Medical Center Detroit, Michigan  48236
Green Bay Oncology - Escanaba Escanaba, Michigan  49431
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Allegiance Health Jackson, Michigan  49201
Sparrow Hospital Lansing, Michigan  48912
Saint Mary Mercy Hospital Livonia, Michigan  48154
Mercy Memorial Hospital Monroe, Michigan  48162
Saint Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Saint Joseph Mercy Port Huron Port Huron, Michigan  48060
Saint Mary's of Michigan Saginaw, Michigan  48601
Lakeland Hospital St. Joseph, Michigan  49085
Saint John Macomb-Oakland Hospital Warren, Michigan  48093
Miller-Dwan Hospital Duluth, Minnesota  55805
Unity Hospital Fridley, Minnesota  55432
Saint John's Hospital - Healtheast Maplewood, Minnesota  55109
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota  55109
North Memorial Medical Health Center Robbinsdale, Minnesota  55422
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota  55416
Saint Joseph's Hospital - Healtheast Saint Paul, Minnesota  55102
Minnesota Oncology and Hematology PA-Woodbury Woodbury, Minnesota  55125
Southeast Missouri Hospital Cape Girardeau, Missouri  63701
Saint John's Regional Medical Center Joplin, Missouri  64804
Missouri Baptist Medical Center Saint Louis, Missouri  63131
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Springfield, Missouri  65802
Saint John's Hospital Springfield, Missouri  65804
Hematology-Oncology Centers of the Northern Rockies PC Billings, Montana  59101
Saint Vincent Healthcare Billings, Montana  59101
Billings Clinic Billings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment Center Butte, Montana  59701
Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator) Great Falls, Montana  59405
Saint Peter's Community Hospital Helena, Montana  59601
Glacier Oncology PLLC Kalispell, Montana  59901
Community Medical Hospital Missoula, Montana  59801
Saint Patrick Hospital - Community Hospital Missoula, Montana  59802
Good Samaritan Hospital Kearney, Nebraska  68847
Portsmouth Regional Hospital Portsmouth, New Hampshire  03802
South Jersey Healthcare Vineland, New Jersey  08360
Orange Regional Medical Center Middletown, New York  10940
Interlakes Foundation Inc-Rochester Rochester, New York  14623
State University of New York Upstate Medical University Syracuse, New York  13210
Mission Hospitals Inc Asheville, North Carolina  28801
Gaston Memorial Hospital Gastonia, North Carolina  28054
Wayne Memorial Hospital Goldsboro, North Carolina  27534
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina  28791
Saint Alexius Medical Center Bismarck, North Dakota  58501
Doctors Hospital Columbus, Ohio  43228
Grant Medical Center Columbus, Ohio  43215
Mount Carmel Health Center West Columbus, Ohio  43222
Good Samaritan Hospital - Dayton Dayton, Ohio  45406
Dayton CCOP Dayton, Ohio  45429
Samaritan North Health Center Dayton, Ohio  45415
Veteran Affairs Medical Center Dayton, Ohio  45428
Hematology Oncology Center Incorporated Elyria, Ohio  44035
Blanchard Valley Hospital Findlay, Ohio  45840
Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio  45005-1066
Kettering Medical Center Kettering, Ohio  45429
Marietta Memorial Hospital Marietta, Ohio  45750
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee, Ohio  43537
Saint Charles Hospital Oregon, Ohio  43616
North Coast Cancer Care Sandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOP Toledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy Hospital Toledo, Ohio  43623
University of Toledo Toledo, Ohio  43614
Saint Vincent Mercy Medical Center Toledo, Ohio  43608
Upper Valley Medical Center Troy, Ohio  45373
Saint Ann's Hospital Westerville, Ohio  43081
Genesis HealthCare System Zanesville, Ohio  43701
Providence Saint Vincent Medical Center Portland, Oregon  97225
Columbia River Oncology Program Portland, Oregon  97225
Pottstown Memorial Medical Center Pottstown, Pennsylvania  19464
Saint Joseph Medical Center Reading, Pennsylvania  19605
Hematology and Oncology Associates of Rhode Island Inc Cranston, Rhode Island  02920
Kent County Hospital Warwick, Rhode Island  02886
Conklin Regional Cancer Center Aberdeen, South Dakota  57401
Fredericksburg Oncology Inc Fredericksburg, Virginia  22401
Harrison Bremerton Hematology and Oncology Bremerton, Washington  98310
Columbia Basin Hematology and Oncology PLLC Kennewick, Washington  99336
Minor and James Medical PLLC Seattle, Washington  98104
The Polyclinic Seattle, Washington  98122
Swedish Medical Center-First Hill Seattle, Washington  98122-4307
West Virginia University Morgantown, West Virginia  26506
Langlade Hospital and Cancer Center Antigo, Wisconsin  54409
Sacred Heart Hospital Eau Claire, Wisconsin  54701
Saint Vincent Hospital Green Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin  54303
Saint Mary's Hospital Green Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin  54301-3526
Dean Hematology and Oncology Clinic Madison, Wisconsin  53717
Bay Area Medical Center Marinette, Wisconsin  54143
Green Bay Oncology - Oconto Falls Oconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer Center Rhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake Center Rice Lake, Wisconsin  54868
Saint Michael's Hospital Stevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
University of Illinois Chicago, Illinois  60612
York Hospital York, Maine  03909
Portneuf Medical Center Pocatello, Idaho  83201
Illinois CancerCare-Bloomington Bloomington%, Illinois  61701
Illinois CancerCare-Canton Canton, Illinois  61520
Illinois CancerCare-Carthage Carthage, Illinois  62321
Illinois CancerCare-Eureka Eureka, Illinois  61530
Illinois CancerCare-Cottage Galesburg, Illinois  61401
Illinois CancerCare-Havana Havana, Illinois  62644
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois  61443
Illinois CancerCare-Macomb Macomb, Illinois  61455
Illinois CancerCare-Monmouth Monmouth, Illinois  61462
DuPage Medical Group-Ogden Naperville, Illinois  60563
Illinois CancerCare-Community Cancer Center Normal, Illinois  61761
Illinois CancerCare-Pekin Pekin, Illinois  61603
Illinois CancerCare-Peru Peru, Illinois  61354
Illinois CancerCare-Princeton Princeton, Illinois  61356
Illinois CancerCare-Spring Valley Spring Valley, Illinois  61362
The Memorial Hospital at Easton Easton, Maryland  21601
Memorial Hospital at Easton - Shore Regional Cancer Center Easton, Maryland  21601
North Coast Cancer Care-Clyde Clyde, Ohio  43410
Erlanger Medical Center Chattanooga, Tennessee  37403
Saint Paul Hospital Dallas, Texas  75235
West Virginia University Charleston Charleston, West Virginia  25304
Riverview Hospital Wisconsin Rapids, Wisconsin  54494
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida  33136
Grady Health System Atlanta, Georgia  30303
Capital Regional Medical Center Jefferson City, Missouri  65101
Hematology Oncology Associates-Berwyn Berwyn, Illinois  60402
Hinsdale Hematology Oncology Associates Incorporated Hinsdale, Illinois  60521
Spector, David MD (UIA Investigator) Moline, Illinois  61265
University of Tennessee - Memphis Memphis, Tennessee  38163
Siouxland Hematology Oncology Associates Sioux City, Iowa  51101
IU Health Arnett Lafayette, Indiana  
Carle Foundation - Carle Cancer Center Urbana, Illinois  61801
Emory University Hospital Midtown Atlanta, Georgia  30308
Eastern Cooperative Oncology Group Boston, Massachusetts  02215
The Toledo Hospital/Toledo Children's Hospital Toledo, Ohio  43606
Genesys Regional Medical Center-West Flint Campus Flint, Michigan  48532
Essentia Health Duluth Clinic CCOP Duluth, Minnesota  55805
Essentia Health Saint Mary's Medical Center Duluth, Minnesota  55805
Sanford Bismarck Medical Center Bismarck, North Dakota  58501
Toledo Clinic Cancer Centers-Oregon Oregon, Ohio  43616
Community Howard Regional Health Kokomo, Indiana  46904
Indiana University Health La Porte Hospital La Porte, Indiana  46350
Saint Joseph Regional Medical Center-Mishawaka Mishawaka, Indiana  46545-1470
PeaceHealth Saint Joseph Medical Center Bellingham, Washington  98225
Illinois Cancer Specialists-Niles Niles, Illinois  60714
Springfield Regional Medical Center Springfield, Ohio  45505
NEA Baptist Memorial Hospital Jonesboro, Arkansas  72401
Edward Hospital/Cancer Center Naperville, Illinois  60540
Toledo Clinic Cancer Centers-Bowling Green Bowling Green, Ohio  43402
Toledo Clinic Cancer Centers-Maumee Maumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-Toledo Toledo, Ohio  43623
PeaceHealth Southwest Medical Center Vancouver, Washington  98664