Trial Information

Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection

Acrochordon, also called soft fibroma, skin tag or fibroepithelial polyp, is a common
cutaneous disorder characterized by a polypoid growth composed of fibroblasts in a loose
collagenous stroma, sometimes with proliferation of blood vessels. They appear as soft,
skin-colored or light brownish skin tumors. Three types of lesions may occur, (1) multiple
small, furrowed papules, especially on the neck and in the axillae, (2) single or multiple
filiform smooth growths in various locations, and (3) solitary bag-like pedunculated growth,
seen most commonly on the lower trunk. Most regard them as a sign of cutaneous aging.

The presence of human papillomaviruses (HPVs), especially the mucosal types, has been
demonstrated in acrochordon. Our previous experience on HPV typing of skin tags also
confirms this finding. Though HPV is a ubiquitous virus, the presence of mucosal type HPV in
non-mucosal sites is exceptional. This investigation is trying to correlate the
clinicopathological and HPV molecular typing of acrochordons. A better understanding of
acrochordon and its relation to HPV infection may improve the ability to prevent and treat.