Trial Information

A Pilot Study for Combined Colon and Endometrial Cancer Screening in Women at High-Risk for Colon and Endometrial Cancer

Women with certain medical conditions have an increased risk for colon and endometrial
cancer. Currently, women go through separate screening procedures. Endometrial biopsies are
performed at a separate visit to the gynecologist, and patients are not sedated for the
procedure. This study will involve performing an endometrial biopsy while you are sedated
for your colonoscopy.

Women who are able to have children must have a negative blood or urine pregnancy test
before they can take part in this study.

As part of the study, you will be asked about your past experience with endometrial biopsy
and colonoscopy. You will be asked about your perception of pain, your expectations, and the
benefits and barriers to the combined screening.

You will then be sedated. The colonoscopy will be performed first by a gastroenterologist.
This will be followed by the endometrial biopsy, which will be performed by a gynecologic
oncologist.

A telephone interview will be performed two weeks after this procedure. The interview will
last about 15 minutes. You will be asked about your perception of pain and the benefits and
barriers to the combined screening.

This is an investigational study. A total of 50 women will take part in this study. All
will be enrolled at M. D. Anderson.