Therapy of Nodal Follicular Lymphoma (Grade I/II) Clinical Stage I or II Using Involved Field Radiotherapy in Combination With Rituximab
The MIR (Mabthera(R) and Involved field Radiation) study is a prospective multicenter trial
combining systemic treatment with the anti CD20 antibody Rituximab (Mabthera(R)) in
combination with involved field radiotherapy (30 - 40 Gy). This trial aims at testing the
combination's efficacy and safety with an accrual of 85 patients.Primary endpoint of the
study is progression free survival. Secondary endpoints are response rate to Rituximab,
complete remission rate at week 18, relapse rate, relapse pattern, relapse free survival,
overall survival, toxicity and quality of life.
More details: Witzens-Harig M, Hensel M, Unterhalt M, Herfarth K. Treatment of limited
stage follicular lymphoma with Rituximab immunotherapy and involved field radiotherapy in a
prospective multicenter Phase II trial-MIR trial. BMC cancer. 2011; 11: 87.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
progression free survival
Klaus Herfarth, MD
University of Heidelberg