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A Phase I Study of a Novel Chemotherapeutic Regimen: Topotecan, Ifosfamide and Carboplatin (TIC) in Children and Young Adults With Solid Tumors-- A Limited Multi-Institution Study

Phase 1
45 Years
Not Enrolling
Solid Tumors

Thank you

Trial Information

A Phase I Study of a Novel Chemotherapeutic Regimen: Topotecan, Ifosfamide and Carboplatin (TIC) in Children and Young Adults With Solid Tumors-- A Limited Multi-Institution Study

All of the chemotherapy drugs used in this study are FDA approved and commercially available
drugs designed to kill cancer cells.

Before you can start treatment on this study, you will have what are called "screening
tests". These tests will help the doctor decide if you are eligible to take part in the
study. You will have a physical exam and routine blood (about 2 teaspoons) and urine tests.
You will have electrocardiogram (ECG - test to measure the electrical activity of the
heart). You will have a chest x-ray and other scans (such as CT, MRI, Bone, Ultrasound or
radionucleotide scans ). You physician will decide which scans are appropriate based on the
disease and clinical situation. You will also have a bone marrow aspirate. To collect a
bone marrow aspirate, an area of the hip or chest bone is numbed with anesthetic and a small
amount of bone marrow is withdrawn through a large needle. Women who are able to have
children must have a negative pregnancy test before starting treatment.

If you are found to be eligible to take part in this study, you will be assigned to a
specific dose of topotecan. The first group of participants will receive a smaller dose of
topotecan. If patients in that group are able to recover a sufficient number of platelets by
Day 22 and no severe side effects are experienced, the next group of participants will be
treated with a larger dose topotecan. The dose will continue to be increased for each new
group of participants until all the participants in a dose group are unable to recover a
sufficient number of platelets by Day 22, or until severe side effects are experienced.
There will be 3 patients in each group. The doses of all the other drugs used on this study
will be the same for every participants.

Topotecan, ifosfamide, and carboplatin will be given for the first three days of each
course. Ifosfamide and carboplatin will be given into a vein for one hour each day along
with the drug mesna. Mesna is not an anti-cancer drug but a drug to help protect the bladder
from the potential damaging effects of ifosfamide. After the first dose of mesna,
participants will receive 3 more doses (one every three hours) over 15-30 minutes .
Topotecan is given directly into a vein for one-half hour beginning one hour after treatment
with ifosfamide, carboplatin, and the first dose of mesna is completed. Participants who
are 22 years or older will only receive Day 1 and 2 of carboplatin.

Starting on the fourth day of each course, you will be given a daily injection of the drug
Filgrastim. Filgrastim is a growth factor naturally produced in the body to stimulate the
production of white blood cells (infection fighting cells). Filgrastim can now be produced
in the laboratory and given to patients at higher doses than the body makes. Filgrastim
should help the body recover from treatment. Filgrastim will be given as an injection under
the skin once a day until an acceptable number of white blood cells are detected in the

A second course of chemotherapy will begin as soon as 21 days after the start of treatment
as long as you have recovered enough white blood cells and platelets. If the white blood
cells and platelets have not recovered by 21 days, you will begin the next course when they
do recover.

After each of the first three courses, you will have a re-evaluation of the disease.
Re-evaluation will require the same scans to be performed as were done at study entry. If
the tumor shows a complete or partial response to the treatment after the second course,
then continuation on the study will be at the discretion of the treating physician. If the
disease is stable, meaning there is no change in the size or degree of the tumor, then
treatment can continue for a total of 3 courses overall.

If the disease gets worse or intolerable side effects occur, you will be taken off study and
other treatment options will be discussed with you.

You may need to be hospitalized during the first three days of each chemotherapy course and
will require visits as an outpatient at other times during treatment to receive laboratory
follow-up and evaluation. Participants may also require hospitalization because of side

During treatment, you will have a physical exam and routine blood (about 2 teaspoons) and
urine tests. You will also have an ECG, a chest x-ray, and other scans as thought
necessary. The physical exam will be done once a week for Courses 1 - 3. The blood tests
will be done on Days 1, 3, 5; then twice weekly and on Day 22 of each course. Urine tests
will be done on Day 1 of each course and at the end of Course 2. The scans and ECG will be
performed at the end of each course or sooner if it is suspected that the disease has
gotten worse.

This is an investigational study. The drugs on this study are FDA approved and commercially
available. However, their use together in this study is experimental. Up to 78 patients will
take part in this study. About 15 patients will be enrolled at UTMDACC.

Inclusion Criteria:

1. Age
2. Histologic proof of solid tumor malignancy (excluding brain stem tumors) at initial
diagnosis. Diagnostic Categories include: a) Sarcoma (Soft Tissue and Bone), b)
Kidney Tumors, c) Brain Tumors, d) Neuroblastoma, e) Hodgkin's disease and
non-Hodgkin's lymphoma, f) Other solid tumors (gonadal and germ cell tumors,
malignant melanoma, retinoblastoma, liver tumors, and miscellaneous tumors)

3. If previously treated, must have radiographic, nuclear image, or biopsy proof that
they have had a recurrence of their disease within 4 weeks prior to study entry.

4. Performance Level: Karnofsky >/= 70% for patients >10 years of age and Lansky
Play-Performance Scale >/=70 for children patients with CNS tumors must have been relatively stable for a minimum of 2 weeks
prior to study entry. Patients who are unable to walk because of paralysis, but who
are up in a wheelchair will be considered ambulatory for the purpose of assessing the
performance score.

5. Life Expectancy >/= 8 weeks.

6. Full recovery from acute toxic effects of all prior chemo, immuno or XRT: a. No
myelosuppressive chemotherapy 7 days since completion of therapy with biologic agent (anti-neoplastic agent). c. No
cranial-spinal &/or spinal (>3600 cGy) XRT. No XRT (including TBI) to > 50% of bone
marrow space. d. No evidence of active GVHD. For allogeneic Stem Cell Transplant
(SCT), >/= 6 months must have elapsed. e. Has NOT received exact combination & dosage
of Topotecan, Carboplatin, & Ifosfamide, as this study recommends, within last 3

7. Adequate Bone Marrow Function: ANC >/=1000/ micro L; Platelets >/= 50,000/ micro L
(transfusion independent); Hgb >/= 8.0 gm/dL (may receive RBC transfusions).

8. Adequate Renal function: Serum creatinine clearance or radioisotope GFR >/= lower limit of normal for age.

9. Adequate Liver function: Total bilirubin 5 x normal for age and albumin >/=2 g/dL.

10. Adequate Cardiac Function: Shortening fraction of >/= 27% by echocardiogram, or
Ejection fraction of >/= 50% by gated radionuclide study.

11. Adequate Pulmonary Function: No evidence of dyspnea at rest, no exercise intolerance,
and a pulse oximetry > 94% if there is clinical indication for determination.

12. Central Nervous System Function: Patients with seizure disorder may be enrolled if on
anticonvulsants and well controlled. CNS toxicity < Grade 2.

13. Signed Informed Consent.

Exclusion Criteria:

1. Pregnancy or Breast Feeding.

2. Prior therapy with this particular topotecan, ifosfamide, carboplatin regimen in last
3 months.

3. Patients with bone marrow solid tumor involvement.

4. Patients having received cranial-spinal and or spinal irradiation (>3600 cGy).
Patients who have received radiation therapy (including TBI) to greater than 50% of
the bone marrow space.

5. Patients with evidence of active graft vs. host disease and/or patients wiht
allogeneic Stem Cell Transplant [SCT], < 6 months.

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Maximum tolerated dose (MTD)

Outcome Time Frame:

Blood tests on Days 1, 3, 5, then twice weekly and on Day 22 of each course; Urine tests done on Day 1 of each course and at end of Course 2.

Safety Issue:


Principal Investigator

Robert J. Wells, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

M.D. Anderson Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

August 2004

Completion Date:

January 2010

Related Keywords:

  • Solid Tumors
  • Solid Tumors
  • Topotecan
  • Hycamtin
  • Ifosfamide
  • Ifex
  • Carboplatin
  • Paraplatin
  • Pediatric
  • Children
  • Young Adults
  • Neoplasms



U.T.M.D. Anderson Cancer Center Houston, Texas  77030