The Effect of Radiation on Semen Quality and Fertility in Men Treated With External Beam Radiation or Brachytherapy for Early Stage Prostate Cancer
18 Years
55 Years
Male
Prostate Cancer
Trial Information
The Effect of Radiation on Semen Quality and Fertility in Men Treated With External Beam Radiation or Brachytherapy for Early Stage Prostate Cancer
Prostate cancer is the most common malignant disease among men. Many young men are diagnosed
with localized prostate cancer. Some of these men are choosing to manage their prostate
cancer with radiation therapy. The radiation therapy delivers minimal dose exposure to
adjacent organs. We hypothesize that when patients are treated with radiation therapy for
localized prostate cancer, decreased fertility can occur due to damage of seminiferous
tubules, which may affect sperm quality. This study will assess the impact of radiation
therapy on semen and seminal fluid.
Inclusion Criteria:
- Subjects with histologically confirmed low risk to moderate stage prostate cancer
(Gleason 6 - 7) treated with brachytherapy or external beam radiation
- > 12 months ago
Exclusion Criteria:
- Subjects with a prior history of infertility
- Subjects who have undergone vasectomy
- Subjects who have received LHRH therapy for prostate cancer < 6 months ago
- Subjects who have received anti-androgens < 3 months ago
- Subjects using alpha blockers within 7 days of specimen provision
- Subjects who have taken finasteride or dutasteride within the previous 4 months.
Type of Study:
Observational
Study Design:
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal, Time Perspective: Prospective
Principal Investigator
Neil Fleshner, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University Health Network, Toronto
Authority:
Canada: Ethics Review Committee
Study ID:
07-0197-CE
NCT ID:
NCT00496249
Start Date:
July 2007
Completion Date:
January 2008
Related Keywords:
- Prostate Cancer
- Prostate
- cancer
- brachytherapy
- radiation
- semen
- fertility
- Prostatic Neoplasms
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